Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMXFY18)

Drug Name

EZN-3042 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting Apoptosis inhibitor survivin (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ISIS 23722	DMQZI7K	Solid tumour/cancer	2A00-2F9Z	Phase 3	[3]
SurVaxM	DMAIGTE	Glioblastoma of brain	2A00.00	Phase 2	[4]
CV-9201	DMCPZYT	Non-small-cell lung cancer	2C25.Y	Phase 1/2	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Apoptosis inhibitor survivin (BIRC5)	TTTPU1G	BIRC5_HUMAN	Modulator	[2]

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References

1	2011 Pipeline of Santaris Pharma.
2	SPC3042: a proapoptotic survivin inhibitor.Mol Cancer Ther.2008 Sep;7(9):2736-45.
3	Targeted BIRC5 silencing using YM155 causes cell death in neuroblastoma cells with low ABCB1 expression.Eur J Cancer.2012 Mar;48(5):763-71.
4	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5	National Cancer Institute Drug Dictionary (drug id 648549).