Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMXHWK6)

Drug Name

Neutralase Drug Info

Synonyms

Heparinase I, IBEX

Indication

Disease Entry	ICD 11	Status	REF
Angiogenesis disorder	BE2Z	Discontinued in Phase 3	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Heparanase (HPSE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Suramin	DMTOUY9	African trypanosomiasis	1F51	Phase 1	[3]
PG-545	DM68D3O	Ocular disease	1F00.1Z	Phase 1	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007559)
2	Heparanase neutralizes the anticoagulation properties of heparin and low-molecular-weight heparin. J Thromb Haemost. 2006 Mar;4(3):560-5.
3	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1728).
4	PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models. Br J Cancer. 2011 Feb 15;104(4):635-42.