General Information of Drug (ID: DMXIH3Q)

Drug Name
BIBW-22 Drug Info
Synonyms RMKP-22; BIBW-22-BS
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Terminated [1]
Cross-matching ID
PubChem CID
132088
CAS Number
CAS 137694-16-7
TTD Drug ID
DMXIH3Q

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Drug(s) Targeting Phosphodiesterase 1 (PDE1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Vinpocetine DMVN2E6 Ischemic stroke 8B11.5Z Approved [3]
ITI-214 DM08TH3 Parkinson disease 8A00.0 Phase 1/2 [4]
ZAPRINAST DMGH3T5 N. A. N. A. Terminated [5]
isobutylmethylxanthine DM46F5X Discovery agent N.A. Investigative [6]
S,S-(2-Hydroxyethyl)Thiocysteine DMLPAD8 Discovery agent N.A. Investigative [7]
BUFROLIN DM61F5W Discovery agent N.A. Investigative [6]
⏷ Show the Full List of 6 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Phosphodiesterase 1 (PDE1) TTHQENC NOUNIPROTAC Inhibitor [2]

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004174)
2 BIBW22 BS, potent multidrug resistance-reversing agent, binds directly to P-glycoprotein and accumulates in drug-resistant cells. Mol Pharmacol. 1996 Sep;50(3):482-92.
3 Effects of phosphodiesterase inhibitors on contraction induced by endothelin-1 of isolated human prostatic tissue. Urology. 2009 Jun;73(6):1397-401.
4 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5 The next generation of phosphodiesterase inhibitors: structural clues to ligand and substrate selectivity of phosphodiesterases. J Med Chem. 2005 May 19;48(10):3449-62.
6 A new generation of phosphodiesterase inhibitors: multiple molecular forms of phosphodiesterase and the potential for drug selectivity. J Med Chem. 1985 May;28(5):537-45.
7 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.