Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMXIUO5)

Drug Name

KT6006 Drug Info

Synonyms

KT 6006; 118736-03-1; 9,12-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-i)(1,6)benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-5,10,16-trihydroxy-9-methyl-1-oxo-, methyl ester, (9S-(9alpha,10alpha,12alpha))-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 196744
CAS Number: CAS 118736-03-1
TTD Drug ID: DMXIUO5

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting DNA topoisomerase I (TOP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[2]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[2]
B-Lactams	DMR8YD6	Bacterial infection	1A00-1C4Z	Approved	[3]
Belotecan hydrocholoride	DM3SRJZ	Small-cell lung cancer	2C25.Y	Approved	[4]
Topetecan	DMAE6LK	Small-cell lung cancer	2C25.Y	Approved	[5]
Karenitecin	DMCRGY4	Lung cancer	2C25.0	Phase 3	[6]
Camptothecin	DM6CHNJ	Solid tumour/cancer	2A00-2F9Z	Phase 3	[7]
Exatecan	DMCA7FN	Solid tumour/cancer	2A00-2F9Z	Phase 3	[8]
Edotecarin	DM3ZL7D	Gastric adenocarcinoma	2B72	Phase 3	[9]
Rubitecan	DMDWU1S	Human immunodeficiency virus infection	1C62	Phase 3	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
DNA topoisomerase I (TOP1)	TTGTQHC	TOP1_HUMAN	Inducer	[1]

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References

1	Induction of mammalian DNA topoisomerase I mediated DNA cleavage by antitumor indolocarbazole derivatives. Biochemistry. 1992 Dec 8;31(48):12069-75.
2	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
3	Luteolin, an emerging anti-cancer flavonoid, poisons eukaryotic DNA topoisomerase I. Biochem J. 2002 Sep 1;366(Pt 2):653-61.
4	Impact of natural products on developing new anti-cancer agents. Chem Rev. 2009 Jul;109(7):3012-43.
5	Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).
6	Characterization of protein kinase chk1 essential for the cell cycle checkpoint after exposure of human head and neck carcinoma A253 cells to a novel topoisomerase I inhibitor BNP1350. Mol Pharmacol.2000 Mar;57(3):453-9.
7	Topoisomerase I inhibitors: camptothecins and beyond. Nat Rev Cancer. 2006 Oct;6(10):789-802.
8	Phase I study of topoisomerase I inhibitor exatecan mesylate (DX-8951f) given as weekly 24-hour infusions three of every four weeks. Clin Cancer Res. 2001 Dec;7(12):3963-70.
9	Edotecarin: a novel topoisomerase I inhibitor. Clin Colorectal Cancer. 2005 May;5(1):27-36.
10	Rubitecan. Expert Opin Investig Drugs. 2006 Jan;15(1):71-9.