Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMXLE71)

Drug Name

SYL-040012 Drug Info

Synonyms

SYL-0012; Beta 2 adrenoceptor-targeting siRNA (ocular hypertension), Sylentis

Indication

Disease Entry	ICD 11	Status	REF
Ocular hypertension	9C61.01	Phase 2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting ADRB2 messenger RNA (ADRB2 mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bamosiran	DM0TZEP	Glaucoma/ocular hypertension	9C61	Phase 2	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	ClinicalTrials.gov (NCT02250612) SYL040012, Treatment for Open Angle Glaucoma. U.S. National Institutes of Health.
2	In vitro and in vivo efficacy of SYL040012, a novel siRNA compound for treatment of glaucoma. Mol Ther. 2014 Jan;22(1):81-91.
3	Clinical pipeline report, company report or official report of Sylentis.