General Information of Drug (ID: DMXLGED)

Drug Name
esuberaprost Drug Info
Synonyms APS-314D free acid; BPS-314d
Indication
Disease Entry ICD 11 Status REF
Gout FA25 Phase 3 [1]
Pulmonary arterial hypertension BB01.0 Phase 3 [2]
Cross-matching ID
PubChem CID
10501053
CAS Number
CAS 94132-88-4
TTD Drug ID
DMXLGED

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Treprostinil DMTIQF3 Pulmonary arterial hypertension BB01.0 Approved [3]
Selexipag DMAHSU0 Pulmonary arterial hypertension BB01.0 Approved [4]
Epoprostenol DMUTYR2 Pulmonary hypertension BB01 Approved [5]
Dinoprost Tromethamine DMXQKSL Abortion JA00 Approved [6]
Misoprostol DMHVJFK Medical abortion JA00.1Z Approved [6]
LAROPIPRANT DM5FABJ Coronary heart disease BA80.Z Phase 4 [7]
Beraprost DMWL182 Pulmonary hypertension BB01 Phase 4 [8]
Ralinepag DM7G4Y9 Pulmonary arterial hypertension BB01.0 Phase 2 [9]
Clinprost DM6E5VA Asthma CA23 Discontinued in Preregistration [10]
Ataprost DMPTG39 Asthma CA23 Discontinued in Phase 3 [11]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Prostacyclin receptor (PTGIR) TTOFYT1 PI2R_HUMAN Agonist [1]

References

1 Specific binding of the new stable epoprostenol analogue beraprost sodium to prostacyclin receptors on human and rat platelets. Arzneimittelforschung. 1989 Apr;39(4):495-9.
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 Dosing considerations in the use of intravenous prostanoids in pulmonary arterial hypertension: an experience-based review. Am Heart J. 2009 Apr;157(4):625-35.
4 Selexipag: an oral, selective prostacyclin receptor agonist for the treatment of pulmonary arterial hypertension. Eur Respir J. 2012 Oct;40(4):874-80.
5 Novel signaling pathways promote a paracrine wave of prostacyclin-induced vascular smooth muscle differentiation. J Mol Cell Cardiol. 2009 May;46(5):682-94.
6 Palmitoylation of the human prostacyclin receptor. Functional implications of palmitoylation and isoprenylation. J Biol Chem. 2003 Feb 28;278(9):6947-58.
7 Discovery of a potent and selective prostaglandin D2 receptor antagonist, [(3R)-4-(4-chloro-benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydroc... J Med Chem. 2007 Feb 22;50(4):794-806.
8 Prostaglandin I2 IP Receptor Agonist, Beraprost, Prevents Transient Global Cerebral Ischemia Induced Hippocampal CA1 Injury in Aging Mice. J Neurol Disord. 2014;2:1000174.
9 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
10 Protective effect of a prostaglandin I2 analog, TEI-7165, on ischemic neuronal damage in gerbils. Brain Res. 1997 Sep 26;769(2):321-8.
11 Pharmacokinetics of intravenous ataprost alfadex, a new prostaglandin I2 analog in healthy volunteers. Int J Clin Pharmacol Ther Toxicol. 1993 Aug;31(8):373-5.