Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMXLS78)

Drug Name
ATPO Drug Info
Synonyms
ATPO; 252930-37-3; (R,S)-2-Amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid; 2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-1,2-oxazol-4-yl]propanoic acid; ATPO, solid; AC1NECDZ; Lopac0_000092; SCHEMBL4318475; CHEMBL265301; GTPL4141; DTXSID70404915; MolPort-003-940-289; HMS3261F20; HMS3260C06; Tox21_500589; Tox21_500092; MFCD03452828; LP00092; LP00589; CCG-204187; NCGC00261274-01; NCGC00260777-01; NCGC00015093-05; NCGC00015093-02; NCGC00093594-01; NCGC00015093-04; NCGC00093594-02; NCGC00015093-03; EU-0100092; A 7845
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
4615193
CAS Number
CAS 252930-37-3
TTD Drug ID
DMXLS78

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Glutamate receptor AMPA 1 (GRIA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
E-2007 DMJDYNQ Diabetic neuropathy 8C0Z Approved [6]
NBQX DMPHZI5 Neurological disorder 6B60 Phase 1 [7]
YM-90K DMWRT4L Convulsion 8A68.Z Discontinued in Phase 2 [8]
Farampator DM76GRQ Major depressive disorder 6A70.3 Discontinued in Phase 1 [9]
GYKI-52466 DM3YG5P Alzheimer disease 8A20 Terminated [10]
GYKI-53655 DMC0JN8 N. A. N. A. Terminated [11]
Zonampanel DM70HZD N. A. N. A. Terminated [8]
SORETOLIDE DMTDLHG Convulsion 8A68.Z Terminated [12]
[3H]kainate DMMK7XU Discovery agent N.A. Investigative [13]
DNQX DMQXPA5 Discovery agent N.A. Investigative [14]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Glutamate receptor AMPA 2 (GRIA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
E-2007 DMJDYNQ Diabetic neuropathy 8C0Z Approved [6]
Paliroden DMX8ZAQ Parkinson disease 8A00.0 Phase 2 [15]
[3H]CNQX DMIFKUX Discovery agent N.A. Investigative [3]
(S)-5-fluorowillardiine DMCIZ7P Discovery agent N.A. Investigative [3]
[3H]AMPA DMLF7SG N. A. N. A. Investigative [3]
Drug(s) Targeting Glutamate receptor AMPA 3 (GRIA3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
E-2007 DMJDYNQ Diabetic neuropathy 8C0Z Approved [6]
[3H]CNQX DMIFKUX Discovery agent N.A. Investigative [4]
(S)-5-fluorowillardiine DMCIZ7P Discovery agent N.A. Investigative [4]
[3H]AMPA DMLF7SG N. A. N. A. Investigative [4]
joro toxin DMYBJ4K Discovery agent N.A. Investigative [4]
Drug(s) Targeting Glutamate receptor AMPA 4 (GRIA4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
E-2007 DMJDYNQ Diabetic neuropathy 8C0Z Approved [6]
[3H]CNQX DMIFKUX Discovery agent N.A. Investigative [5]
(S)-5-fluorowillardiine DMCIZ7P Discovery agent N.A. Investigative [5]
[3H]AMPA DMLF7SG N. A. N. A. Investigative [5]
joro toxin DMYBJ4K Discovery agent N.A. Investigative [5]
AMG-889436 DMKP8L9 Parkinson disease 8A00.0 Investigative [5]
⏷ Show the Full List of 6 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Glutamate receptor AMPA 1 (GRIA1) TTVPQTF GRIA1_HUMAN Antagonist [2]
Glutamate receptor AMPA 2 (GRIA2) TT9HLZ0 GRIA2_HUMAN Antagonist [3]
Glutamate receptor AMPA 3 (GRIA3) TT82EZV GRIA3_HUMAN Antagonist [4]
Glutamate receptor AMPA 4 (GRIA4) TTPJR0G GRIA4_HUMAN Antagonist [5]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4141).
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 444).
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 445).
4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 446).
5 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 447).
6 Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.
7 Structural investigation of the 7-chloro-3-hydroxy-1H-quinazoline-2,4-dione scaffold to obtain AMPA and kainate receptor selective antagonists. Syn... J Med Chem. 2006 Oct 5;49(20):6015-26.
8 Synthesis and AMPA receptor antagonistic activity of a novel 7-imidazolyl-6-trifluoromethyl quinoxalinecarboxylic acid with a substituted phenyl gr... Bioorg Med Chem Lett. 2004 Oct 18;14(20):5107-11.
9 The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22.
10 New 7,8-ethylenedioxy-2,3-benzodiazepines as noncompetitive AMPA receptor antagonists. Bioorg Med Chem Lett. 2006 Jan 1;16(1):167-70.
11 Substituted 1,2-dihydrophthalazines: potent, selective, and noncompetitive inhibitors of the AMPA receptor. J Med Chem. 1996 Jan 19;39(2):343-6.
12 Preclinical pharmacology of perampanel, a selective non-competitive AMPA receptor antagonist. Acta Neurol Scand Suppl. 2013;(197):19-24.
13 1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. structure-activity relationships and identification of pot... J Med Chem. 2008 Oct 23;51(20):6614-8.
14 Synthesis of chiral 1-(2'-amino-2'-carboxyethyl)-1,4-dihydro-6,7-quinoxaline-2,3-diones: alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate recep... J Med Chem. 1996 Oct 25;39(22):4430-8.
15 Mechanism of inhibition of the GluA2 AMPA receptor channel opening by talampanel and its enantiomer: the stereochemistry of the 4-methyl group on the diazepine ring of 2,3-benzodiazepine derivatives.ACS Chem Neurosci.2013 Apr 17;4(4):635-44.