Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMXM19W)

Drug Name
dequalinium Drug Info
Synonyms
dequalinium; Dequadin; 6707-58-0; UNII-E7QC7V26B8; Dequavagyn; Decamine; Labosept; Sorot; GNF-Pf-5483; E7QC7V26B8; CHEBI:41872; Polycidine; Dequavet; Dekadin; Rumilet; Dekamin; Sentril; Sanoral; Oralgol; Ivazil; Dequadin chloride; Dequalin chloride; C30H40N4; DEQ; 1,1'-decane-1,10-diylbis(4-amino-2-methylquinolinium); Solvidont; Quinolinium, 1,1'-(1,10-decanediyl)bis(4-amino-2-methyl-; 1-[10-(4-amino-2-methylquinolyl)decyl]-2-methyl-4-quinolylamine; CHEMBL121663
Indication
Disease Entry ICD 11 Status REF
Myelopathy 8B42 Clinical trial [1]
Cross-matching ID
PubChem CID
2993
ChEBI ID
CHEBI:41872
CAS Number
CAS 6707-58-0
TTD Drug ID
DMXM19W

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Investigative Drug(s)
Discontinued Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Calcium-activated potassium channel KCa2.3 (KCNN3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
[14C]TEA DM6SFYH Discovery agent N.A. Investigative [6]
EBIO DMPKI0N Discovery agent N.A. Investigative [6]
UCL1684 DMZNJFU Discovery agent N.A. Investigative [7]
DC-EBIO DM2T5OV Discovery agent N.A. Investigative [8]
UCL1848 DM2CN0A Discovery agent N.A. Investigative [7]
apamin DMYNBK5 Discovery agent N.A. Investigative [7]
CyPPA DM64L9I Discovery agent N.A. Investigative [9]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Targeting Calcium-activated potassium channel KCa2.1 (KCNN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
[14C]TEA DM6SFYH Discovery agent N.A. Investigative [6]
EBIO DMPKI0N Discovery agent N.A. Investigative [6]
UCL1684 DMZNJFU Discovery agent N.A. Investigative [6]
UCL1848 DM2CN0A Discovery agent N.A. Investigative [10]
apamin DMYNBK5 Discovery agent N.A. Investigative [2]
Drug(s) Targeting Cyclic nucleotide-gated channel alpha-2 (CNGA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
L-(cis)-diltiazem DMK07MI Discovery agent N.A. Investigative [11]
all-trans-retinal DM6CEVB Discovery agent N.A. Investigative [12]
PIP3 DMJX39N Discovery agent N.A. Investigative [13]
Drug(s) Targeting Calcium-activated potassium channel KCa2.2 (KCNN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
zoxazolamine DM70TKB Multiple myeloma 2A83 Terminated [14]
[14C]TEA DM6SFYH Discovery agent N.A. Investigative [6]
EBIO DMPKI0N Discovery agent N.A. Investigative [6]
UCL1684 DMZNJFU Discovery agent N.A. Investigative [2]
DC-EBIO DM2T5OV Discovery agent N.A. Investigative [15]
UCL1848 DM2CN0A Discovery agent N.A. Investigative [16]
apamin DMYNBK5 Discovery agent N.A. Investigative [17]
CyPPA DM64L9I Discovery agent N.A. Investigative [9]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Targeting Cyclic nucleotide-gated channel alpha-1 (CNGA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
L-(cis)-diltiazem DMK07MI Discovery agent N.A. Investigative [18]
H-8 DM80QF9 Discovery agent N.A. Investigative [19]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Calcium-activated potassium channel KCa2.1 (KCNN1) TT9R6BE KCNN1_HUMAN Blocker (channel blocker) [2]
Calcium-activated potassium channel KCa2.2 (KCNN2) TT2T5M0 KCNN2_HUMAN Blocker (channel blocker) [3]
Calcium-activated potassium channel KCa2.3 (KCNN3) TT9JH25 KCNN3_HUMAN Blocker (channel blocker) [1]
Cyclic nucleotide-gated channel alpha-1 (CNGA1) TTHIQMC CNGA1_HUMAN Blocker (channel blocker) [4]
Cyclic nucleotide-gated channel alpha-2 (CNGA2) TT8SJGB CNGA2_HUMAN Blocker (channel blocker) [5]

References

1 Pharmacological characterisation of the human small conductance calcium-activated potassium channel hSK3 reveals sensitivity to tricyclic antidepressants and antipsychotic phenothiazines. Neuropharmacology. 2001 May;40(6):772-83.
2 Pharmacological characterization of small-conductance Ca(2+)-activated K(+) channels stably expressed in HEK 293 cells. Br J Pharmacol. 2000 Mar;129(5):991-9.
3 Block of rat brain recombinant SK channels by tricyclic antidepressants and related compounds. Eur J Pharmacol. 2000 Jul 28;401(1):1-7.
4 Dequalinium: a novel, high-affinity blocker of CNGA1 channels. J Gen Physiol. 2003 Jan;121(1):37-47.
5 State-dependent block of CNG channels by dequalinium. J Gen Physiol. 2004 Mar;123(3):295-304.
6 Small conductance calcium-activated potassium channels: from structure to function. Prog Neurobiol. 2010 Jul;91(3):242-55.
7 SK3 is an important component of K(+) channels mediating the afterhyperpolarization in cultured rat SCG neurones. J Physiol. 2001 Sep 1;535(Pt 2):323-34.
8 Modulators of small- and intermediate-conductance calcium-activated potassium channels and their therapeutic indications. Curr Med Chem. 2007;14(13):1437-57.
9 Selective positive modulation of the SK3 and SK2 subtypes of small conductance Ca2+-activated K+ channels. Br J Pharmacol. 2007 Jul;151(5):655-65.
10 The pharmacology of hSK1 Ca2+-activated K+ channels expressed in mammalian cell lines. Br J Pharmacol. 2000 Feb;129(4):627-30.
11 Primary structure and functional expression of a cyclic nucleotide-activated channel from olfactory neurons. Nature. 1990 Sep 13;347(6289):184-7.
12 All-trans-retinal shuts down rod cyclic nucleotide-gated ion channels: a novel role for photoreceptor retinoids in the response to bright light Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8372-7.
13 Interplay between PIP3 and calmodulin regulation of olfactory cyclic nucleotide-gated channels. Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15635-40.
14 Modulation of recombinant small-conductance Ca(2+)-activated K(+) channels by the muscle relaxant chlorzoxazone and structurally related compounds. J Pharmacol Exp Ther. 2001 Mar;296(3):683-9.
15 Specific enhancement of SK channel activity selectively potentiates the afterhyperpolarizing current I(AHP) and modulates the firing properties of ... J Biol Chem. 2005 Dec 16;280(50):41404-11.
16 Calcium-activated potassium channels sustain calcium signaling in T lymphocytes. Selective blockers and manipulated channel expression levels. J Biol Chem. 2001 Apr 13;276(15):12249-56.
17 SK2 encodes the apamin-sensitive Ca(2+)-activated K(+) channels in the human leukemic T cell line, Jurkat. FEBS Lett. 2000 Mar 10;469(2-3):196-202.
18 A new subunit of the cyclic nucleotide-gated cation channel in retinal rods. Nature. 1993 Apr 22;362(6422):764-7.
19 Direct blockade of both cloned rat rod photoreceptor cyclic nucleotide-gated non-selective cation (CNG) channel alpha-subunit and native CNG channels from Xenopus rod outer segments by H-8, a non-specific cyclic nucleotide-dependent protein kinase inhibitor. Neurosci Lett. 1997 Sep 12;233(1):37-40.