Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMXQCBU)

Drug Name

Valtorcitabine Drug Info

Synonyms

Epcitabine; Torcitabine; LDC-300; NV-02C; L-2-deoxycytidine; Val-L-dC; Beta-L-2`-deoxycytidine; L-dC prodrug, Idenix/Novartis; L-dC, Idenix/Novartis

Indication

Disease Entry	ICD 11	Status	REF
Hepatitis virus infection	1E50-1E51	Discontinued in Phase 2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Hepatitis B virus Polymerase (HBV P)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Telbivudine	DMSWUGE	Hepatitis B virus infection	1E51.0	Approved	[3]
ATI-2173	DMT5QYJ	Hepatitis B	1E51	Phase 2	[4]
NCO-48	DMUSPW5	Hepatitis B virus infection	1E51.0	Phase 1	[5]
------------------------------------------------------------------------------------

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Hepatitis B virus Polymerase (HBV P)	TTT4SY6	Q67889_HBV	Inhibitor	[2]

------------------------------------------------------------------------------------

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013710)
2	Prodrugs of nucleoside analogues for improved oral absorption and tissue targeting. J Pharm Sci. 2008 Mar;97(3):1109-34.
3	Nucleos(t)ide analogues for hepatitis B virus: strategies for long-term success. Best Pract Res Clin Gastroenterol. 2008;22(6):1081-92.
4	ATI-2173, a Novel Liver-Targeted Non-Chain-Terminating Nucleotide for Hepatitis B Virus Cure Regimens. Antimicrob Agents Chemother. 2020 Aug 20;64(9):e00836-20.
5	Safety, Tolerability and Pharmacokinetics of NCO-48 Fumarate in Healthy Subjects