Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMXQGKL)

Drug Name

CB-813 Drug Info

Synonyms

CB-813d; Recombinant human factor VIIa (Alterase, hemophilia), Catalyst Biosciences; RhFVIIa (Alterase, hemophilia), Catalyst Biosciences; Recombinant human factor VIIa (Alterase, hemophilia), Catalyst Biosciences/Wyeth Pharmaceuticals

Indication

Disease Entry	ICD 11	Status	REF
Hemophilia	3B10.0	Phase 1	[1]

Cross-matching ID

PubChem CID: 208688
CAS Number: CAS 32808-74-5
TTD Drug ID: DMXQGKL

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Coagulation factor VII (F7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Factor viia	DMZUW6P	Hemophilia	3B10.0	Approved	[3]
Vatreptacog alfa (activated)	DMANKTO	Bleeding disorder	GA20-GA21	Phase 3	[4]
BAX-817	DMB147A	Hemophilia	3B10.0	Phase 3	[5]
Activated recombinant FVII-albumin fusion protein	DMKY9GI	Hemophilia	3B10.0	Phase 2/3	[6]
Recombinant factor VIIa PEGylated liposomal	DMY3TAD	Factor VII deficiency	3B14	Phase 1/2	[3]
F-7TG	DML4JXZ	Hemophilia	3B10.0	Phase 1	[3]
Eptacog alfa	DMAQYRL	Hemophilia	3B10.0	Phase 1	[7]
BAY 86-6150	DM6R3WC	Hemophilia	3B10.0	Discontinued in Phase 2/3	[8]
RNAPc2	DME9V0I	Colorectal cancer	2B91.Z	Discontinued in Phase 2	[9]
Fucose	DMAHMSV	N. A.	N. A.	Investigative	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Coagulation factor VII (F7)	TTF0EGX	FA7_HUMAN	Modulator	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027663)
2	Clinical pipeline report, company report or official report of Catalyst Biosciences.
3	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2363).
4	Recombinant factor VIIa analog (vatreptacog alfa [activated]) for treatment of joint bleeds in hemophilia patients with inhibitors: a randomized controlled trial. J Thromb Haemost. 2012 Jan;10(1):81-9.
5	Clinical pipeline report, company report or official report of Baxter.
6	ClinicalTrials.gov (NCT01542619) A Safety and Pharmacokinetics Study of a Recombinant Fusion Protein Linking Coagulation Factor VIIa With Albumin (rVIIa-FP) in Healthy Male Volunteers. U.S. National Institutes of Health.
7	Recombinant factor VIIa (eptacog alfa): a review of its use in congenital hemophilia with inhibitors, acquired hemophilia, and other congenital bleeding disorders. BioDrugs. 2008;22(2):121-36.
8	Bayer HealthCare and Maxygen Announce Hematology Agreement. U.S. Securities and Exchange Commission. July 2, 2008.
9	rNAPc2 inhibits colorectal cancer in mice through tissue factor. Clin Cancer Res. 2009 Jan 1;15(1):208-16.
10	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.