General Information of Drug (ID: DMXSEHF)

Drug Name
Y-39983 Drug Info
Synonyms RKI-983; SNJ-1656; ROCK inhibitors, Mitsubishi Tanabe Pharma/Senju/Novartis; Rho-associated protein kinase inhibitors, Mitsubishi Tanabe Pharma/Senju/Novartis
Indication
Disease Entry ICD 11 Status REF
Glaucoma/ocular hypertension 9C61 Phase 1/2 [1]
Cross-matching ID
PubChem CID
9810884
ChEBI ID
CHEBI:91412
CAS Number
CAS 199433-58-4
TTD Drug ID
DMXSEHF

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Netarsudil DM0LPI9 Open-angle glaucoma 9C61 Approved [3]
Ximelegatran DMU8ANS Myocardial infarction BA41-BA43 Approved [4]
Roclatan DMVQ5X1 Glaucoma/ocular hypertension 9C61 Phase 3 [5]
AR-12286 DM5TC43 Glaucoma/ocular hypertension 9C61 Phase 2 [6]
AMA-76 DMBWNX5 Glaucoma/ocular hypertension 9C61 Phase 2 [7]
Cethrin DMD3XMW Spinal cord injury ND51.2 Phase 1/2 [8]
STM 434 DMDF29A Ovarian cancer 2C73 Phase 1 [9]
AT13148 DMYIPKJ Solid tumour/cancer 2A00-2F9Z Phase 1 [10]
Hexahydro azepinone derivative 1 DMC1ZIX N. A. N. A. Patented [9]
Isoquinoline sulfonyl derivative 2 DMT5E7M N. A. N. A. Patented [9]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Rho-associated protein kinase (ROCK) TTMQO60 NOUNIPROTAC Modulator [2]

References

1 ClinicalTrials.gov (NCT00846989) Efficacy, Tolerability and Safety of RKI983 (0.05% & 0.10%) vs Xalatan in Patients With POAG or Ocular Hypertension. U.S. National Institutes of Health.
2 Effects of Y-39983, a selective Rho-associated protein kinase inhibitor, on blood flow in optic nerve head in rabbits and axonal regeneration of retinal ganglion cells in rats.Curr Eye Res. 2011 Oct;36(10):964-70.
3 Effect of 0.04% AR-13324, a ROCK, and norepinephrine transporter inhibitor, on aqueous humor dynamics in normotensive monkey eyes. J Glaucoma. 2015 Jan;24(1):51-4.
4 Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases. Mol Pharmacol. 2000 May;57(5):976-83.
5 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
6 Ocular hypotensive effect of the Rho kinase inhibitor AR-12286 in patients with glaucoma and ocular hypertension. Am J Ophthalmol. 2011 Nov;152(5):834-41.e1.
7 AMA0076, a novel, locally acting Rho kinase inhibitor, potently lowers intraocular pressure in New Zealand white rabbits with minimal hyperemia. Invest Ophthalmol Vis Sci. 2014 Feb 18;55(2):1006-16.
8 A phase I/IIa clinical trial of a recombinant Rho protein antagonist in acute spinal cord injury. J Neurotrauma. 2011 May;28(5):787-96.
9 Rho kinase inhibitors: a patent review (2014 - 2016).Expert Opin Ther Pat. 2017 Apr;27(4):507-515.
10 Company report (Astex)