Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMXSFA0)

Drug Name

ALV-003 Drug Info

Synonyms

Gluten-detoxifying protease (celiac sprue), Alvine Pharmaceuticals; Glutamine-specific cysteine protease (EP-B2) + proline-specific prolyl endopeptidase (PEP) (celiac disease), Alvine

Indication

Disease Entry	ICD 11	Status	REF
Coeliac disease	DA95	Phase 2	[1]

Cross-matching ID

TTD Drug ID: DMXSFA0

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Prolyl endopeptidase (PREP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BAICALEIN	DM4C7E6	Influenza virus infection	1E30-1E32	Phase 2	[3]
ONO-1603	DMKIZAL	Cognitive impairment	6D71	Phase 2	[4]
S-17092-1	DMYR1K8	Cognitive impairment	6D71	Phase 1	[5]
JTP-4819	DMI0UJS	Cognitive impairment	6D71	Discontinued in Phase 2	[6]
Z-321	DMLO2QY	Parkinson disease	8A00.0	Discontinued in Phase 1	[7]
BAICALIN	DMY1TLZ	Human immunodeficiency virus infection	1C62	Terminated	[8]
Y-29794	DMLAVES	N. A.	N. A.	Terminated	[8]
Double Oxidized Cysteine	DM6TU84	Discovery agent	N.A.	Investigative	[9]
Monothioglycerol	DMENSOZ	Discovery agent	N.A.	Investigative	[9]
Z-Pro-Prolinal	DM43O2U	Discovery agent	N.A.	Investigative	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Prolyl endopeptidase (PREP)	TTNGKET	PPCE_HUMAN	Modulator	[2]

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References

1	ClinicalTrials.gov (NCT00959114) Safety and Efficacy of ALV003 for the Treatment of Celiac Disease. U.S. National Institutes of Health.
2	The effects of ALV003 pre-digestion of gluten on immune response and symptoms in celiac disease in vivo. Clin Immunol. 2010 Mar;134(3):289-95.
3	Baicalin, a prodrug able to reach the CNS, is a prolyl oligopeptidase inhibitor. Bioorg Med Chem. 2008 Aug 1;16(15):7516-24.
4	ONO-1603, a potential antidementia drug, shows neuroprotective effects and increases m3-muscarinic receptor mRNA levels in differentiating rat cerebellar granule neurons. Neurosci Lett. 1996 Aug 23;214(2-3):151-4.
5	Effect of S 17092, a novel prolyl endopeptidase inhibitor, on substance P and alpha-melanocyte-stimulating hormone breakdown in the rat brain. J Neurochem. 2003 Mar;84(5):919-29.
6	A novel prolyl endopeptidase inhibitor, JTP-4819, with potential for treating Alzheimer's disease. Behav Brain Res. 1997 Feb;83(1-2):147-51.
7	Z-321, a prolyl endopeptidase inhibitor, augments the potentiation of synaptic transmission in rat hippocampal slices. Behav Brain Res. 1997 Feb;83(1-2):213-6.
8	Inhibitors of prolyl oligopeptidases for the therapy of human diseases: defining diseases and inhibitors. J Med Chem. 2010 May 13;53(9):3423-38.
9	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
10	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.