Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMY0A9E)

Drug Name

Hydroxycitric acid Drug Info

Synonyms

SCHEMBL4050699; AKOS021667799; AKOS001495053; ES-2021; MCULE-2991610180; EU-0054396; SR-01000546484; SR-01000546484-1

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Pancreatic alpha-amylase (AMY2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pancrecarb	DMOML9Q	Pancreatic malfunction	DC30-DC3Z	NDA filed	[2]
Liprotamase	DMNF4UH	Cystic fibrosis	CA25	Phase 3	[3]
Beta-D-Glucose	DM5IHYP	Discovery agent	N.A.	Investigative	[4]
Pyroglutamic Acid	DMROZUA	Discovery agent	N.A.	Investigative	[4]
Acanthus ilicifolius Linn	DMZDFRI	Discovery agent	N.A.	Investigative	[5]
6-Deoxy-Alpha-D-Glucose	DM9HBY5	Discovery agent	N.A.	Investigative	[4]
Acarbose Derived Hexasaccharide	DMS9COH	Discovery agent	N.A.	Investigative	[4]
Maltosyl-Alpha (1,4)-D-Gluconhydroximo-1,5-Lactam	DMMY542	Discovery agent	N.A.	Investigative	[6]
Alpha-acarviosinyl-(1-->9)-3-alpha-D-glucopyranosylpropen	DM4IXUQ	Discovery agent	N.A.	Investigative	[7]
Alpha-acarviosinyl-(1-->7)-3-alpha-D-glucopyranosylpropen	DMHV14R	Discovery agent	N.A.	Investigative	[7]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Pancreatic alpha-amylase (AMY2A)	TTCGSZ4	AMYP_HUMAN	Inhibitor	[1]

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References

1	Chemistry, physiological properties, and microbial production of hydroxycitric acid. Appl Microbiol Biotechnol. 2007 Jul;75(5):977-82.
2	Clinical pipeline report, company report or official report of Digestive Care.
3	Clinical pipeline report, company report or official report of Anthera Pharmaceuticals.
4	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
5	Four acarviosin-containing oligosaccharides identified from Streptomyces coelicoflavus ZG0656 are potent inhibitors of alpha-amylase. Carbohydr Res. 2008 Apr 7;343(5):882-92.
6	DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
7	Enzymatic synthesis of a selective inhibitor for alpha-glucosidases: alpha-acarviosinyl-(1-->9)-3-alpha-D-glucopyranosylpropen. J Agric Food Chem. 2008 Jul 9;56(13):5324-30.