Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMY1XJH)

Drug Name

AMG 570 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Systemic lupus erythematosus	4A40.0	Phase 2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting B-cell-activating factor (TNFSF13B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Belimumab	DM3OBQF	Membranous glomerulonephritis		Approved	[3]
Blisibimod	DM7V9LH	Systemic lupus erythematosus	4A40.0	Phase 3	[4]
Tabalumab	DMKSAG1	Multiple myeloma	2A83	Phase 3	[5]
BR3-Fc	DMFN1WI	Idiopathic thrombocytopenic purpura	3B64.10	Discontinued in Phase 2	[6]
LymphoRad-131	DMDUM0Z	Lymphoma	2A80-2A86	Discontinued in Phase 1	[7]
Receptor-Fc fusion proteins	DM4B6FO	Discovery agent	N.A.	Investigative	[8]
1,4-Diethylene Dioxide	DMI36WC	Discovery agent	N.A.	Investigative	[9]
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Drug(s) Targeting B7-related protein 1 (B7RP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AMG 557	DME6QH1	Sjogren syndrome	4A43.20	Phase 2	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
B-cell-activating factor (TNFSF13B)	TTWMIDN	TN13B_HUMAN	Inhibitor	[2]
B7-related protein 1 (B7RP1)	TTB9Z8R	ICOSL_HUMAN	Inhibitor	[2]

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References

1	ClinicalTrials.gov (NCT04058028) Efficacy and Safety of AMG 570 in Subjects With Active Systemic Lupus Erythematosus (SLE). U.S. National Institutes of Health.
2	Development of an ICOSL and BAFF bispecific inhibitor AMG 570 for systemic lupus erythematosus treatment. Clin Exp Rheumatol. Nov-Dec 2019;37(6):906-914.
3	Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).
4	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5	Tabalumab, an anti-BAFF monoclonal antibody, in patients with active rheumatoid arthritis with an inadequate response to TNF inhibitors. Ann Rheum Dis. 2013 Sep 1;72(9):1461-8.
6	Emerging drugs for idiopathic thrombocytopenic purpura in adults. Expert Opin Emerg Drugs. 2008 Jun;13(2):237-54.
7	Fusion Toxin BLyS-Gelonin Inhibits Growth of Malignant Human B Cell Lines In Vitro and In Vivo. PLoS One. 2012; 7(10): e47361.
8	BAFF: B cell survival factor and emerging therapeutic target for autoimmune disorders. Expert Opin Ther Targets. 2003 Feb;7(1):115-23.
9	DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
10	Administration Of AMG 557, A Human Anti-B7RP-1 (ICOSL) Antibody, Leads To The Selective Inhibition Of Anti-KLH IgG Responses In Subjects With SLE: Results Of A Phase 1 Randomized, Double-Blind, Placebo-Controlled, Sequential, Rising, Multiple-Dose Study. San Diego, CA October 25-30, 2013