Details of the Drug

General Information of Drug (ID: DME6QH1)

Drug Name
AMG 557
Indication
Disease Entry ICD 11 Status REF
Sjogren syndrome 4A43.20 Phase 2 [1]
Systemic lupus erythematosus 4A40.0 Phase 2 [2]
Cross-matching ID
TTD ID
D0V0UH
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
B7-related protein 1 (B7RP1) TTB9Z8R ICOSL_HUMAN Modulator [3]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 ClinicalTrials.gov (NCT02334306) A Phase 2a, Randomized, Placebo Controlled, Study to Evaluate the Safety and Efficacy of AMG 557/MEDI5872 in Primary Sj ren's Syndrome. U.S. National Institutes of Health.
3 Administration Of AMG 557, A Human Anti-B7RP-1 (ICOSL) Antibody, Leads To The Selective Inhibition Of Anti-KLH IgG Responses In Subjects With SLE: Results Of A Phase 1 Randomized, Double-Blind, Placebo-Controlled, Sequential, Rising, Multiple-Dose Study. San Diego, CA October 25-30, 2013