Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMY4IWC)

• Drug Name: LCB-2183 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Asthma	CA23	Phase 2	[1]

• Cross-matching ID:
  PubChem CID: 135418284
  CAS Number: CAS 133914-85-9
  TTD Drug ID: DMY4IWC

Molecule-Related Drug Atlas

Drug(s) Targeting Histamine receptor (HR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Histamine Phosphate	DMV7IM6	Diagnostic imaging	N.A.	Approved	[3]
Repirinast	DM6KI0D	Asthma	CA23	Approved	[4]
Levomequitazine	DMAYC76	Seasonal allergic rhinitis	CA08.01	Phase 3	[5]
ETX-9101	DMZOA2L	Asthma	CA23	Phase 2	[6]
ETS-6218	DMV96BY	Fibromyalgia	MG30.01	Phase 2	[6]
Votucalis	DMW4LTI	Allergic rhinitis	CA08.0	Phase 2	[7]
OX-NLA	DMPEHBJ	Allergic rhinitis	CA08.0	Discontinued in Phase 3	[8]
Tesmilifene	DMPB36I	Breast cancer	2C60-2C65	Discontinued in Phase 2	[9]
CP-118	DMNJD9H	Allergic rhinitis	CA08.0	Discontinued in Phase 2	[10]
REV-598	DM314CZ	Carcinoid syndrome	5B10	Terminated	[11]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Histamine receptor (HR)	TT7CXIM	NOUNIPROTAC	Modulator	[2]

References

• [1] LCB 2183 inhibits tracheal hyperreactivity and pulmonary inflammation in mouse airways. Eur J Pharmacol. 1995 Aug 25;282(1-3):103-9.
• [2] LCB 2183 inhibits the inflammation associated with oxazolone-induced contact sensitivity. Int J Immunopharmacol. 1994 Aug;16(8):675-83.
• [3] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [4] Mechanism of action of MY-1250, an active metabolite of Repirinast, in inhibiting histamine release from rat mast cells. Br J Pharmacol. 1992 Mar;105(3):587-90.
• [5] Oxidation of histamine H1 antagonist mequitazine is catalyzed by cytochrome P450 2D6 in human liver microsomes. J Pharmacol Exp Ther. 1998 Feb;284(2):437-42.
• [6] Clinical pipeline report, company report or official report of e-Therapeutics.
• [7] CA patent application no. 520580, Histamine binding compounds for treatment method for disease conditions mediated by neutrophils.
• [8] Clinical pipeline report, company report or official report of Orexo.
• [9] Effects of tesmilifene, a substrate of CYP3A and an inhibitor of P-glycoprotein, on the pharmacokinetics of intravenous and oral docetaxel in rats. J Pharm Pharmacol. 2010 Aug;62(8):1084-8.
• [10] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025139)
• [11] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800016819)