Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMY9ZGN)

Drug Name

VT-111a Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Acute coronary syndrome	BA41	Phase 2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Preclinical Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Serine protease unspecific (SP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nafamostat	DMU1XOD	Pancreatitis	DC31-DC34	Approved	[3]
Gabexate	DMU9D2F	Pancreatitis	DC31-DC34	Approved	[3]
Aprotinin	DM0QD4W	Bleeding disorder	GA20-GA21	Approved	[4]
Sivelestat sodium hydrate	DMOSJD0	Acute lung injury	NB32.3	Phase 4	[5]
Camostat	DMQ7UL8	Cystic fibrosis	CA25	Phase 2	[6]
Sepimostat mesylate	DMRBYH8	Solid tumour/cancer	2A00-2F9Z	Discontinued in Phase 3	[7]
VT-111	DMOY15R	Graft rejection in heart transplantation	NE84	Preclinical	[8]
NPI-1999	DMH1YL8	Thrombosis	DB61-GB90	Terminated	[9]
SDZ-MTH-958	DMKCXBJ	Artery stenosis	BD52	Terminated	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Serine protease unspecific (SP)	TTEMV5X	NOUNIPROTAC	Modulator	[2]

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References

1	Clinical pipeline report, company report or official report of Avarx.
2	Viral Serpin Therapeutics: From Concept to Clinic. Methods Enzymol. 2011; 499: 301-329.
3	Tryptase-positive mast cells correlate with angiogenesis in early breast cancer patients. Int J Oncol. 2009 Jul;35(1):115-20.
4	Randomized controlled trials of aprotinin in cardiac surgery: could clinical equipoise have stopped the bleeding Clin Trials. 2005;2(3):218-29; discussion 229-32.
5	Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91.
6	Camostat mesilate inhibits prostasin activity and reduces blood pressure and renal injury in salt-sensitive hypertension. J Hypertens. 2009 Jan;27(1):181-9.
7	Effect of FUT-187, oral serine protease inhibitor, on inflammation in the gastric remnant. Gan To Kagaku Ryoho. 1996 Dec;23(14):1971-9.
8	New developments in immunosuppressive therapy for heart transplantation. Expert Opin Emerg Drugs. 2009 Mar;14(1):1-21.
9	US patent application no. 2005,0096,323, Diketopiperazine derivatives to inhibit thrombin.
10	Thrombin inhibition in an ex vivo model of porcine heart xenograft hyperacute rejection. Transplantation. 1996 Mar 27;61(6):862-8.