Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMYAB79)

Drug Name
NH-3 Drug Info
Synonyms
thyromimetic, 5b; NH-3; CHEMBL109279; JMC496635 Compound 5; GTPL2633; SCHEMBL16993604; BDBM18885; 2-[4-({4-hydroxy-3-[2-(4-nitrophenyl)ethynyl]-5-(propan-2-yl)phenyl}methyl)-3,5-dimethylphenoxy]acetic acid; 2-[4-[[4-hydroxy-3-[2-(4-nitrophenyl)ethynyl]-5-propan-2-ylphenyl]methyl]-3,5-dimethylphenoxy]acetic acid
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
10027822
TTD Drug ID
DMYAB79

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Thyroid hormone receptor (THR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
B7-2/GM-CSF DM0LKHV Dementia 6D80-6D86 Phase 1 [3]
KB-5359 DMM7S3V Lipid metabolism disorder 5C52.Z Terminated [4]
Neplanocin A DMXULGK Discovery agent N.A. Investigative [2]
GC-14 DMYMGBA Discovery agent N.A. Investigative [2]
NH-4 DMSUZFO Discovery agent N.A. Investigative [2]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Thyroid hormone receptor (THR) TTQWUPT NOUNIPROTAC Antagonist [2]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2633).
2 Design of thyroid hormone receptor antagonists from first principles. J Steroid Biochem Mol Biol. 2002 Dec;83(1-5):59-73.
3 Sobetirome: a case history of bench-to-clinic drug discovery and development. Heart Fail Rev. 2010 Mar;15(2):177-82.
4 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.