Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMYBJ4K)

Drug Name

joro toxin Drug Info

Synonyms

Joro spider toxin; Joro toxin; JSTX-3; 112163-33-4; Joro Spider Toxin 3; AC1L3P2K; CHEMBL313747; CHEBI:34802; Butanediamide, N1-(5-((3-((4-((3-aminopropyl)amino)butyl)amino)-1-oxopropyl)amino)pentyl)-2-(((2,4-dihydroxyphenyl)acetyl)amino)-, (2S)-; (2S)-N-[5-[3-[4-(3-aminopropylamino)butylamino]propanoylamino]pentyl]-2-[[2-(2,4-dihydroxyphenyl)acetyl]amino]butanediamide; GTPL4229; CTK8E9607; DTXSID50149933; ZINC4654981; BDBM50105843; RT-013407; FT-0771159; C13931; J-002718

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 119582
ChEBI ID: CHEBI:34802
CAS Number: CAS 112163-33-4
TTD Drug ID: DMYBJ4K

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Glutamate receptor AMPA 1 (GRIA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
E-2007	DMJDYNQ	Diabetic neuropathy	8C0Z	Approved	[5]
NBQX	DMPHZI5	Neurological disorder	6B60	Phase 1	[6]
YM-90K	DMWRT4L	Convulsion	8A68.Z	Discontinued in Phase 2	[7]
Farampator	DM76GRQ	Major depressive disorder	6A70.3	Discontinued in Phase 1	[8]
GYKI-52466	DM3YG5P	Alzheimer disease	8A20	Terminated	[9]
GYKI-53655	DMC0JN8	N. A.	N. A.	Terminated	[10]
Zonampanel	DM70HZD	N. A.	N. A.	Terminated	[7]
SORETOLIDE	DMTDLHG	Convulsion	8A68.Z	Terminated	[11]
[3H]kainate	DMMK7XU	Discovery agent	N.A.	Investigative	[12]
DNQX	DMQXPA5	Discovery agent	N.A.	Investigative	[13]
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Drug(s) Targeting Glutamate receptor AMPA 3 (GRIA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
E-2007	DMJDYNQ	Diabetic neuropathy	8C0Z	Approved	[5]
[3H]CNQX	DMIFKUX	Discovery agent	N.A.	Investigative	[3]
ATPO	DMXLS78	Discovery agent	N.A.	Investigative	[3]
(S)-5-fluorowillardiine	DMCIZ7P	Discovery agent	N.A.	Investigative	[3]
[3H]AMPA	DMLF7SG	N. A.	N. A.	Investigative	[3]
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Drug(s) Targeting Glutamate receptor AMPA 4 (GRIA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
E-2007	DMJDYNQ	Diabetic neuropathy	8C0Z	Approved	[5]
[3H]CNQX	DMIFKUX	Discovery agent	N.A.	Investigative	[4]
ATPO	DMXLS78	Discovery agent	N.A.	Investigative	[4]
(S)-5-fluorowillardiine	DMCIZ7P	Discovery agent	N.A.	Investigative	[4]
[3H]AMPA	DMLF7SG	N. A.	N. A.	Investigative	[4]
AMG-889436	DMKP8L9	Parkinson disease	8A00.0	Investigative	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glutamate receptor AMPA 1 (GRIA1)	TTVPQTF	GRIA1_HUMAN	Blocker (channel blocker)	[2]
Glutamate receptor AMPA 3 (GRIA3)	TT82EZV	GRIA3_HUMAN	Blocker (channel blocker)	[3]
Glutamate receptor AMPA 4 (GRIA4)	TTPJR0G	GRIA4_HUMAN	Blocker (channel blocker)	[4]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4229).
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 444).
3	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 446).
4	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 447).
5	Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.
6	Structural investigation of the 7-chloro-3-hydroxy-1H-quinazoline-2,4-dione scaffold to obtain AMPA and kainate receptor selective antagonists. Syn... J Med Chem. 2006 Oct 5;49(20):6015-26.
7	Synthesis and AMPA receptor antagonistic activity of a novel 7-imidazolyl-6-trifluoromethyl quinoxalinecarboxylic acid with a substituted phenyl gr... Bioorg Med Chem Lett. 2004 Oct 18;14(20):5107-11.
8	The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22.
9	New 7,8-ethylenedioxy-2,3-benzodiazepines as noncompetitive AMPA receptor antagonists. Bioorg Med Chem Lett. 2006 Jan 1;16(1):167-70.
10	Substituted 1,2-dihydrophthalazines: potent, selective, and noncompetitive inhibitors of the AMPA receptor. J Med Chem. 1996 Jan 19;39(2):343-6.
11	Preclinical pharmacology of perampanel, a selective non-competitive AMPA receptor antagonist. Acta Neurol Scand Suppl. 2013;(197):19-24.
12	1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. structure-activity relationships and identification of pot... J Med Chem. 2008 Oct 23;51(20):6614-8.
13	Synthesis of chiral 1-(2'-amino-2'-carboxyethyl)-1,4-dihydro-6,7-quinoxaline-2,3-diones: alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate recep... J Med Chem. 1996 Oct 25;39(22):4430-8.