General Information of Drug (ID: DMYEALO)

Drug Name
TMC-647055 Drug Info
Synonyms
TMC647055; 1204416-97-6; TMC-647055; UNII-11BD024G7J; TMC 647055; 11BD024G7J; 113-cyclohexyl-13-methoxy-5,11-dimethyl-17H-8-oxa-4-thia-3,5,11-triaza-1(10,6)-benzo[3,4]azepino[1,2-a]indolacyclododecaphane-2,12-dione 4,4-dioxide; TMC647055 Choline; SCHEMBL1239667; CHEMBL2043025; DTXSID90152860; BDBM243456; EX-A1252; AOB87185; BCP06459; ZINC84726167; AKOS030627003; SB16907; DB11822; NCGC00482982-02; DA-47229; BC600546; 2,19-Methano-3,7:4,1-dimetheno-1H,11H-14,10,2,9,11,17-benzoxathiatetraazacyclodocosine-8,18(9H,15H)-dione, 27-cycl
Indication
Disease Entry ICD 11 Status REF
Hepatitis C virus infection 1E51.1 Phase 1 [1]
Cross-matching ID
PubChem CID
44556044
CAS Number
CAS 1204416-97-6
TTD Drug ID
DMYEALO

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PSI-7977 DMLSUWZ HCV 1-6 infection 1E51 Approved [3]
Setrobuvir DMTNDM2 Hepatitis C virus infection 1E51.1 Phase 2 [4]
BI 207127 DMMSGAT Hepatitis C virus infection 1E51.1 Phase 2 [5]
Valopicitabine dihydrochloride DMFWZ2U Virus infection 1A24-1D9Z Phase 2 [6]
INX-189 DMSTJ6Q Hepatitis C virus infection 1E51.1 Phase 2 [7]
Tegobuvir DM6YI5T Hepatitis C virus infection 1E51.1 Phase 2 [8]
VX-759 DMJUSM8 Hepatitis C virus infection 1E51.1 Phase 2 [9]
VX-135 DMZ3FE8 Hepatitis C virus infection 1E51.1 Phase 2 [10]
VX-222 DMO3U4W Hepatitis C virus infection 1E51.1 Phase 2 [9]
BMS 791325 DMKH4PI Hepatitis C virus infection 1E51.1 Phase 2 [11]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B) TTMVBWH POLG_HCV1 Inhibitor [2]

References

1 ClinicalTrials.gov (NCT01202825) TMC647055HPC1001 - First-in-human Trial to Examine Safety, Tolerability and Pharmacokinetics (How the Drug is Absorbed Into the Bloodstream) of Increasing Single OralDoses and of Increasing Repeated Oral Doses of TMC647055 in Healthy Volunteers and in Hepatitis C Virus Infected Patients. U.S. National Institutes of Health.
2 WO patent application no. 2014,1522,75, Deuterium modified derivatives of the ns5b polymerase inhibitor tmc647055.
3 Radium 223 dichloride for prostate cancer treatment. Drug Des Devel Ther. 2017 Sep 6;11:2643-2651.
4 Clinical pipeline report, company report or official report of Anadys Pharmaceuticals (2011).
5 2011 Pipeline of Boehringer Ingelheim Pharma.
6 Valopicitabine dihydrochloride:a specific polymerase inhibitor of hepatitis C virus. Curr Opin Investig Drugs. 2007 Feb;8(2):150-8.
7 Clinical pipeline report, company report or official report of Bristol-Myers Squibb.
8 Clinical pipeline report, company report or official report of Gilead (2011).
9 2011 Pipeline of Vertex.
10 All-oral HCV therapies near approval. Nat Rev Drug Discov. 2013 Jun;12(6):409-11.
11 2011 Pipeline of Bristol-Myers Squibb.