Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMYF60K)

Drug Name

6-Hydroxymethyl-7,8-Dihydropterin Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Discontinued Drug(s)

Investigative Drug(s)

Preclinical Drug(s)

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Drug(s) Targeting Bacterial Dihydroneopterinaldolase (Bact folB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bropirimine	DMMT1YQ	Virus infection	1A24-1D9Z	Discontinued in Phase 3	[1]
7,8-dihydrobiopterin	DMQU4XM	Discovery agent	N.A.	Investigative	[1]
7,8-Dihydroneopterin	DM5TXY1	Discovery agent	N.A.	Investigative	[1]
9-Methylguanine	DM54FRI	Discovery agent	N.A.	Investigative	[1]
8-Amino-1,3-Dimethyl-3,7-Dihydropurine-2,6-Dione	DM84D9W	Discovery agent	N.A.	Investigative	[1]
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Drug(s) Targeting Bacterial Hydroxymethyl-dihydropterin pyrophosphokinase (Bact folK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PD-157695	DMDSR1X	Schizophrenia	6A20	Preclinical	[2]
Acetate Ion	DMD08RH	Discovery agent	N.A.	Investigative	[1]
[3H]alphabeta-meATP	DMWV5C3	Discovery agent	N.A.	Investigative	[1]
[Pterin-6-Yl Methanyl]-Phosphonophosphate	DM4ZY79	Discovery agent	N.A.	Investigative	[1]
6-Hydroxymethylpterin	DM7EWDN	Discovery agent	N.A.	Investigative	[3]
P(1)-(6-Hydroxymethylpterin)-P(4)-(5'-adenosyl)tetraphosphate	DMOY627	Discovery agent	N.A.	Investigative	[2]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial Dihydroneopterinaldolase (Bact folB)	TTG9CFY	FOLB_ECOLI	Inhibitor	[1]
Bacterial Hydroxymethyl-dihydropterin pyrophosphokinase (Bact folK)	TT38ECI	HPPK_ECOLI	Inhibitor	[1]

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References

1	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2	Bisubstrate analogue inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: synthesis and biochemical and crystallographic studies. J Med Chem. 2001 Apr 26;44(9):1364-71.
3	DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.