Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMYHEUA)

Drug Name

ASN007 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Preclinical Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Extracellular signal-regulated kinase 1 (ERK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BVD-523	DMNB4XK	Melanoma	2C30	Phase 2	[2]
HH2710	DM0C5MV	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[3]
ASTX029	DMVZXIA	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[4]
VAN-10-4-eluting stent	DM3ZW6A	Artery stenosis	BD52	Phase 1	[5]
GDC-0994	DMFC2OY	Solid tumour/cancer	2A00-2F9Z	Phase 1	[6]
JSI-1187	DMVJWBS	Solid tumour/cancer	2A00-2F9Z	Phase 1	[7]
COR-D	DMLXMCB	T-cell leukaemia	2A90	Preclinical	[8]
6-[(E)-2-(4-Fluoro-phenyl)-vinyl]-9H-purine	DMDNG8F	Discovery agent	N.A.	Investigative	[9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Extracellular signal-regulated kinase 1 (ERK1)	TT1MG9E	MK03_HUMAN	Inhibitor	[1]

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References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	DOI: 10.1158/1538-7445.AM2015-4693
3	Clinical pipeline report, company report or official report of HaiHe Biopharma.
4	Clinical pipeline report, company report or official report of Astex Pharmaceuticals.
5	WO patent application no. 2013,1850,32, Nanotherapeutics for drug targeting.
6	ERK Mutations Confer Resistance to Mitogen-Activated Protein Kinase Pathway Inhibitors
7	National Cancer Institute Drug Dictionary (drug name JSI1187).
8	Corchorusin-D directed apoptosis of K562 cells occurs through activation of mitochondrial and death receptor pathways and suppression of AKT/PKB pathway. Cell Physiol Biochem. 2012;30(4):915-26.
9	Synthesis and biological testing of purine derivatives as potential ATP-competitive kinase inhibitors. J Med Chem. 2005 Feb 10;48(3):710-22.