Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMYKPXJ)

Drug Name

9cUAB-30 Drug Info

Synonyms

UAB-112; UAB-20; UAB-30; UAB-75; UAB-76; UAB-8; Retinoic acid analogs (cancer), University of Alabama; (9Z)-UAB-30

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Retinoic acid receptor RXR-gamma (RXRG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[2]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[3]
NRX-4204	DMYXOU2	Diabetic complication	5A2Y	Phase 2	[4]
IRX4204	DM9SCME	Breast cancer	2C60-2C65	Phase 1	[5]
SR-11237	DMQG3CK	Solid tumour/cancer	2A00-2F9Z	Terminated	[6]
AGN-34	DM5ECDM	Discovery agent	N.A.	Investigative	[7]
LG100754	DMEK4FY	Discovery agent	N.A.	Investigative	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Retinoic acid receptor RXR-gamma (RXRG)	TTH029C	RXRG_HUMAN	Modulator	[1]

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References

1	In vitro metabolic characterization, phenotyping, and kinetic studies of 9cUAB30, a retinoid X receptor-specific retinoid. Drug Metab Dispos. 2007 Jul;35(7):1157-64.
2	Vitamins and cofactors: highlights of ESBOC 2009. Nat Chem Biol. 2009 Aug;5(8):530-3.
3	Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids. Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):30-4.
4	DOI: 10.1038/scibx.2010.766
5	Selective brain penetrable Nurr1 transactivator for treating Parkinson's disease.Oncotarget.2016 Feb 16;7(7):7469-79.
6	Silicon analogues of the RXR-selective retinoid agonist SR11237 (BMS649): chemistry and biology. ChemMedChem. 2009 Jul;4(7):1143-52.
7	Farnesoid X receptor: from structure to potential clinical applications. J Med Chem. 2005 Aug 25;48(17):5383-403.
8	Activation of specific RXR heterodimers by an antagonist of RXR homodimers. Nature. 1996 Oct 3;383(6599):450-3.