General Information of Drug (ID: DMYKZB3)

Drug Name
Anti-DR5 cells Drug Info
Indication
Disease Entry ICD 11 Status REF
Hepatocellular carcinoma 2C12.02 Phase 1/2 [1]
Cross-matching ID
TTD Drug ID
DMYKZB3

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Drug(s) Targeting TRAIL receptor 2 (TRAIL-R2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Conatumumab DM2UOSN Colorectal cancer 2B91.Z Phase 2 [2]
Lexatumumab DMOS5JZ Solid tumour/cancer 2A00-2F9Z Phase 2 [3]
IGM-8444 DMFJXDZ Hematologic tumour 2B33.Y Phase 1 [4]
INBRX-109 DMUNSPI Solid tumour/cancer 2A00-2F9Z Phase 1 [5]
BI 905711 DME9NYV Solid tumour/cancer 2A00-2F9Z Phase 1 [6]
DS-8273 DMJPUDW Colorectal cancer 2B91.Z Phase 1 [7]
GEN1029 DMV8IWJ Solid tumour/cancer 2A00-2F9Z Phase 1 [8]
RhApo2L/TRAIL DMIAZJ9 Solid tumour/cancer 2A00-2F9Z Discontinued in Phase 1/2 [2]
LBY-135 DMSRD5U Solid tumour/cancer 2A00-2F9Z Discontinued in Phase 1 [9]
HGS-TR2J DM0W2TA Solid tumour/cancer 2A00-2F9Z Discontinued in Phase 1 [10]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
TRAIL receptor 2 (TRAIL-R2) TTW20TU TR10B_HUMAN CAR-T-Cell-Therapy [1]

References

1 ClinicalTrials.gov (NCT03638206) Autologous CAR-T/TCR-T Cell Immunotherapy for Malignancies
2 Clinical pipeline report, company report or official report of Amgen (2009).
3 National Cancer Institute Drug Dictionary (drug id 528015).
4 Clinical pipeline report, company report or official report of IGM Biosciences.
5 Clinical pipeline report, company report or official report of Inhibrx.
6 Selective Tumor Cell Apoptosis and Tumor Regression in CDH17-Positive Colorectal Cancer Models using BI 905711, a Novel Liver-Sparing TRAILR2 Agonist. Mol Cancer Ther. 2021 Jan;20(1):96-108.
7 First-in-human study of the antibody DR5 agonist DS-8273a in patients with advanced solid tumors. Invest New Drugs. 2017 Jun;35(3):298-306.
8 National Cancer Institute Drug Dictionary (drug name Tilogotamab).
9 Safety, pharmacokinetics, and pharmacodynamics of the DR5 antibody LBY135 alone and in combination with capecitabine in patients with advanced solid tumors. Invest New Drugs. 2014 Feb;32(1):135-44.
10 Enhancement of Glioma Radiation Therapy and Chemotherapy Response with Targeted Antibody Therapy Against Death Receptor 5. Int J Radiat Oncol Biol Phys. 2008 June 1; 71(2): 507-516.