Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMYM9JL)

Drug Name

PT-14 Drug Info

Synonyms

Erectide; PT-14 (transmucosal); PT-14 (transmucosal), Palatin/TheraTech

Indication

Disease Entry	ICD 11	Status	REF
Erectile dysfunction	HA01.1	Discontinued in Phase 2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Preclinical Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Melanocortin receptor 4 (MC4R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylnaltrexone bromide	DMZTGN2	Opioid-induced constipation	DB32.1	Approved	[3]
Bremelanotide	DM20LIM	Hypoactive sexual desire dysfunction	HA00	Approved	[4]
Setmelanotide	DMPVRN9	Obesity	5B81	Approved	[5]
Amylin	DMWDEN0	N. A.	N. A.	Phase 4	[6]
AMG 386	DMQJXL4	Breast cancer	2C60-2C65	Phase 3	[3]
PMX-53	DMZUAJ4	Atopic dermatitis	EA80	Phase 2	[7]
PF-446687	DML38VU	Female sexual arousal dysfunction	HA01.1	Phase 2	[8]
AP-1030	DMBGA35	Metabolic disorder	5C50-5D2Z	Phase 1/2	[9]
PF-07258669	DM3CJ5N	Malnutrition	5B50-5B71	Phase 1	[10]
Melanotetan II	DMYK8MV	Obesity	5B81	Preclinical	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010143)
2	The protective effects of the melanocortin receptor (MCR) agonist, melanotan-II (MTII), against binge-like ethanol drinking are facilitated by deletion of the MC3 receptor in mice. Neuropeptides. 2014 Feb;48(1):47-51.
3	Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60.
4	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
5	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020
6	Novel anti-obesity drugs. Expert Opin Investig Drugs. 2000 Jun;9(6):1317-26.
7	Peptidomimetic C5a receptor antagonists with hydrophobic substitutions at the C-terminus: increased receptor specificity and in vivo activity. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5088-92.
8	Melanocortin Receptor Agonists Facilitate Oxytocin-Dependent Partner Preference Formation in the Prairie Vole. Neuropsychopharmacology. 2015 Jul;40(8):1856-65.
9	Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
10	Discovery of the Potent and Selective MC4R Antagonist PF-07258669 for the Potential Treatment of Appetite Loss. J Med Chem. 2023 Mar 9;66(5):3195-3211.