General Information of Drug (ID: DMYNBK5)

Drug Name
apamin Drug Info
Synonyms 08APA001_SMARTOX; GTPL2311; 08APA001; Apamin, synthetic, > Apamin, from bee venom, &gt
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
16218850
TTD Drug ID
DMYNBK5
VARIDT Drug ID
DR00806

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Investigative Drug(s)
Discontinued Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
dequalinium DMXM19W Myelopathy 8B42 Clinical trial [5]
[14C]TEA DM6SFYH Discovery agent N.A. Investigative [6]
EBIO DMPKI0N Discovery agent N.A. Investigative [6]
UCL1684 DMZNJFU Discovery agent N.A. Investigative [4]
DC-EBIO DM2T5OV Discovery agent N.A. Investigative [7]
UCL1848 DM2CN0A Discovery agent N.A. Investigative [4]
CyPPA DM64L9I Discovery agent N.A. Investigative [8]
⏷ Show the Full List of 7 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
dequalinium DMXM19W Myelopathy 8B42 Clinical trial [2]
[14C]TEA DM6SFYH Discovery agent N.A. Investigative [6]
EBIO DMPKI0N Discovery agent N.A. Investigative [6]
UCL1684 DMZNJFU Discovery agent N.A. Investigative [6]
UCL1848 DM2CN0A Discovery agent N.A. Investigative [9]
Drug Name Drug ID Indication ICD 11 Highest Status REF
dequalinium DMXM19W Myelopathy 8B42 Clinical trial [10]
zoxazolamine DM70TKB Multiple myeloma 2A83 Terminated [11]
[14C]TEA DM6SFYH Discovery agent N.A. Investigative [6]
EBIO DMPKI0N Discovery agent N.A. Investigative [6]
UCL1684 DMZNJFU Discovery agent N.A. Investigative [2]
DC-EBIO DM2T5OV Discovery agent N.A. Investigative [12]
UCL1848 DM2CN0A Discovery agent N.A. Investigative [13]
CyPPA DM64L9I Discovery agent N.A. Investigative [8]
⏷ Show the Full List of 8 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Calcium-activated potassium channel KCa2.1 (KCNN1) TT9R6BE KCNN1_HUMAN Blocker (channel blocker) [2]
Calcium-activated potassium channel KCa2.2 (KCNN2) TT2T5M0 KCNN2_HUMAN Blocker (channel blocker) [3]
Calcium-activated potassium channel KCa2.3 (KCNN3) TT9JH25 KCNN3_HUMAN Blocker (channel blocker) [4]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2311).
2 Pharmacological characterization of small-conductance Ca(2+)-activated K(+) channels stably expressed in HEK 293 cells. Br J Pharmacol. 2000 Mar;129(5):991-9.
3 SK2 encodes the apamin-sensitive Ca(2+)-activated K(+) channels in the human leukemic T cell line, Jurkat. FEBS Lett. 2000 Mar 10;469(2-3):196-202.
4 SK3 is an important component of K(+) channels mediating the afterhyperpolarization in cultured rat SCG neurones. J Physiol. 2001 Sep 1;535(Pt 2):323-34.
5 Pharmacological characterisation of the human small conductance calcium-activated potassium channel hSK3 reveals sensitivity to tricyclic antidepressants and antipsychotic phenothiazines. Neuropharmacology. 2001 May;40(6):772-83.
6 Small conductance calcium-activated potassium channels: from structure to function. Prog Neurobiol. 2010 Jul;91(3):242-55.
7 Modulators of small- and intermediate-conductance calcium-activated potassium channels and their therapeutic indications. Curr Med Chem. 2007;14(13):1437-57.
8 Selective positive modulation of the SK3 and SK2 subtypes of small conductance Ca2+-activated K+ channels. Br J Pharmacol. 2007 Jul;151(5):655-65.
9 The pharmacology of hSK1 Ca2+-activated K+ channels expressed in mammalian cell lines. Br J Pharmacol. 2000 Feb;129(4):627-30.
10 Block of rat brain recombinant SK channels by tricyclic antidepressants and related compounds. Eur J Pharmacol. 2000 Jul 28;401(1):1-7.
11 Modulation of recombinant small-conductance Ca(2+)-activated K(+) channels by the muscle relaxant chlorzoxazone and structurally related compounds. J Pharmacol Exp Ther. 2001 Mar;296(3):683-9.
12 Specific enhancement of SK channel activity selectively potentiates the afterhyperpolarizing current I(AHP) and modulates the firing properties of ... J Biol Chem. 2005 Dec 16;280(50):41404-11.
13 Calcium-activated potassium channels sustain calcium signaling in T lymphocytes. Selective blockers and manipulated channel expression levels. J Biol Chem. 2001 Apr 13;276(15):12249-56.