Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMYNFIP)

Drug Name

5-methyl orotate Drug Info

Synonyms

AC1LAAV1; SCHEMBL15531476; 4-[4-[[11-butyl-9-[(R)-cyclohexyl(hydroxy)methyl]-7,10-dioxo-3,8,11-triazaspiro[5.5]undecan-3-yl]methyl]phenoxy]benzoic acid

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 464989
TTD Drug ID: DMYNFIP

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting Plasmodium Dihydroorotase (Malaria dho)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Orotate	DMMB29S	Discovery agent	N.A.	Investigative	[1]
Lysine Nz-Carboxylic Acid	DMW1YK3	Discovery agent	N.A.	Investigative	[2]
Dihydroorotate	DM76BGZ	Discovery agent	N.A.	Investigative	[2]
5-Fluoro orotate	DMLSC10	Discovery agent	N.A.	Investigative	[1]
5-bromo orotate	DM0HCG6	Discovery agent	N.A.	Investigative	[1]
N-Carbamoyl-L-Aspartate	DMJ13TR	Discovery agent	N.A.	Investigative	[2]
5-iodo orotate	DMDKFIO	Discovery agent	N.A.	Investigative	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Plasmodium Dihydroorotase (Malaria dho)	TT09NOX	A9CSR1_PLAFA	Inhibitor	[1]

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References

1	Antimalarial activity of orotate analogs that inhibit dihydroorotase and dihydroorotate dehydrogenase. Biochem Pharmacol. 1992 Mar 17;43(6):1295-301.
2	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.