Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMYOUB6)

• Drug Name: EMA-401 Drug Info
• Synonyms: Neuropathic pain targeting small molecules (postherpetic neuralgia), Spinifex

Indication

Disease Entry	ICD 11	Status	REF
Peripheral neuropathy	8C0Z	Phase 2	[1]
Postherpetic neuralgia	1E91.5	Phase 2	[2]

• Cross-matching ID:
  PubChem CID: 9937291
  CAS Number: CAS 1316755-16-4
  TTD Drug ID: DMYOUB6

Molecule-Related Drug Atlas

Drug(s) Targeting Angiotensin II receptor type-2 (AGTR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ANGIOTENSIN II	DMLWQ27	Increase blood pressure	BA04	Approved	[4]
SARALASIN	DMKS1DV	Hypertension	BA00-BA04	Approved	[5]
MP-157	DM5VXWO	Hypertension	BA00-BA04	Phase 1	[6]
PMID25416646-Compound-Figure5-E	DMYO7VH	N. A.	N. A.	Patented	[7]
Phenylpyridine derivative 3	DMDT5JI	N. A.	N. A.	Patented	[7]
1-(biphenyl-4-yl-methyl)-1H-imidazole derivative 1	DMGYZQ2	N. A.	N. A.	Patented	[7]
Fonsartan	DM15LAP	Hypertension	BA00-BA04	Discontinued in Phase 2	[8]
L-158282	DMKSEIY	N. A.	N. A.	Discontinued in Phase 2	[9]
TAK-591	DM25DB4	Hypertension	BA00-BA04	Discontinued in Phase 1	[10]
L-159689	DM9JE7Y	Hypertension	BA00-BA04	Terminated	[11]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Angiotensin II receptor type-2 (AGTR2)	TTQVOEI	AGTR2_HUMAN	Antagonist	[3]

References

• [1] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8374).
• [3] Clinical pipeline report, company report or official report of Spinifex.
• [4] The preparation of (perfluoroalkyl)imidazoles as nonpeptide angiotensin II receptor antagonists, Bioorg. Med. Chem. Lett. 3(5):895-898 (1993).
• [5] cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain... J Med Chem. 2008 Nov 27;51(22):7094-8.
• [6] As drug target reemerges, the question is to block or stimulate it. Nature Medicine. Spoonful of Medicine. 05 Feb 2014. Cassandra Willyard
• [7] PPAR ligands and their therapeutic applications: a patent review (2008 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):175-91.
• [8] Role of the angiotensin II AT2-subtype receptors in the blood pressure-lowering effect of losartan in salt-restricted rats. J Hypertens. 1998 Dec;16(12 Pt 2):2039-43.
• [9] Subtituted phenylthiophene benzoylsulfonamides with potent binding affinity to angiotensin II AT1 and AT2 receptors, Bioorg. Med. Chem. Lett. 4(1):189-194 (1994).
• [10] Clinical pipeline report, company report or official report of Takeda (2009).
• [11] The design, binding affinity prediction and synthesis of macrocyclic angiotensin II AT1 and AT2 receptor antagonists, Bioorg. Med. Chem. Lett. 6(8):923-928 (1996).