General Information of Drug (ID: DMYOUB6)

Drug Name
EMA-401 Drug Info
Synonyms Neuropathic pain targeting small molecules (postherpetic neuralgia), Spinifex
Indication
Disease Entry ICD 11 Status REF
Peripheral neuropathy 8C0Z Phase 2 [1]
Postherpetic neuralgia 1E91.5 Phase 2 [2]
Cross-matching ID
PubChem CID
9937291
CAS Number
CAS 1316755-16-4
TTD Drug ID
DMYOUB6

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Discontinued Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
ANGIOTENSIN II DMLWQ27 Increase blood pressure BA04 Approved [4]
SARALASIN DMKS1DV Hypertension BA00-BA04 Approved [5]
MP-157 DM5VXWO Hypertension BA00-BA04 Phase 1 [6]
PMID25416646-Compound-Figure5-E DMYO7VH N. A. N. A. Patented [7]
Phenylpyridine derivative 3 DMDT5JI N. A. N. A. Patented [7]
1-(biphenyl-4-yl-methyl)-1H-imidazole derivative 1 DMGYZQ2 N. A. N. A. Patented [7]
Fonsartan DM15LAP Hypertension BA00-BA04 Discontinued in Phase 2 [8]
L-158282 DMKSEIY N. A. N. A. Discontinued in Phase 2 [9]
TAK-591 DM25DB4 Hypertension BA00-BA04 Discontinued in Phase 1 [10]
L-159689 DM9JE7Y Hypertension BA00-BA04 Terminated [11]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Angiotensin II receptor type-2 (AGTR2) TTQVOEI AGTR2_HUMAN Antagonist [3]

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8374).
3 Clinical pipeline report, company report or official report of Spinifex.
4 The preparation of (perfluoroalkyl)imidazoles as nonpeptide angiotensin II receptor antagonists, Bioorg. Med. Chem. Lett. 3(5):895-898 (1993).
5 cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain... J Med Chem. 2008 Nov 27;51(22):7094-8.
6 As drug target reemerges, the question is to block or stimulate it. Nature Medicine. Spoonful of Medicine. 05 Feb 2014. Cassandra Willyard
7 PPAR ligands and their therapeutic applications: a patent review (2008 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):175-91.
8 Role of the angiotensin II AT2-subtype receptors in the blood pressure-lowering effect of losartan in salt-restricted rats. J Hypertens. 1998 Dec;16(12 Pt 2):2039-43.
9 Subtituted phenylthiophene benzoylsulfonamides with potent binding affinity to angiotensin II AT1 and AT2 receptors, Bioorg. Med. Chem. Lett. 4(1):189-194 (1994).
10 Clinical pipeline report, company report or official report of Takeda (2009).
11 The design, binding affinity prediction and synthesis of macrocyclic angiotensin II AT1 and AT2 receptor antagonists, Bioorg. Med. Chem. Lett. 6(8):923-928 (1996).