Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMYPJC3)

• Drug Name: Oleanonic acid Drug Info
• Synonyms: 3-Oxoolean-12-en-28-oic Acid

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 12313704
  CAS Number: CAS 17990-42-0
  TTD Drug ID: DMYPJC3

Molecule-Related Drug Atlas

Drug(s) Targeting PTPN1 messenger RNA (PTPN1 mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[3]
TRYPAN BLUE	DM4NTMO	Ophthalmic surgery injury	PK97	Approved	[4]
URSOLIC ACID	DM4SOAW	Metabolic syndrome x	5C50-5D2Z	Phase 2	[5]
ISIS 113715	DMUPD4G	Type-2 diabetes	5A11	Phase 2	[6]
ISIS-PTP1Brx	DMJGVXT	Type-2 diabetes	5A11	Phase 2	[7]
ERTIPROTAFIB	DMJXEV7	Type-2 diabetes	5A11	Terminated	[8]
Acetate Ion	DMD08RH	Discovery agent	N.A.	Investigative	[9]
B-Octylglucoside	DMMO75G	Discovery agent	N.A.	Investigative	[9]
2-Methyl-2,4-Pentanediol	DMD45CU	Discovery agent	N.A.	Investigative	[9]
Double Oxidized Cysteine	DM6TU84	Discovery agent	N.A.	Investigative	[9]

Drug(s) Targeting Glycogen phosphorylase muscle form (GP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
URSOLIC ACID	DM4SOAW	Metabolic syndrome x	5C50-5D2Z	Phase 2	[10]
JTT-651	DMGP42Q	Type-2 diabetes	5A11	Discontinued in Phase 1	[11]
L-serine-O-phosphate	DMTJ1NH	Discovery agent	N.A.	Investigative	[9]
Beta-D-Glucose	DM5IHYP	Discovery agent	N.A.	Investigative	[9]
Indirubin-5-sulfonate	DM08VHZ	Discovery agent	N.A.	Investigative	[9]
Inosinic Acid	DMLR86H	Discovery agent	N.A.	Investigative	[9]
Alpha-D-Glucose-6-Phosphate	DMR0EVN	Discovery agent	N.A.	Investigative	[9]
N'-Pyridoxyl-Lysine-5'-Monophosphate	DM3ZHBO	Discovery agent	N.A.	Investigative	[9]
OLEANOLIC_ACID	DMWDMJ3	Discovery agent	N.A.	Investigative	[1]
Nojirimycine Tetrazole	DMYZRTB	Discovery agent	N.A.	Investigative	[12]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glycogen phosphorylase muscle form (GP)	TTZHY6R	PYGM_HUMAN	Inhibitor	[1]
PTPN1 messenger RNA (PTPN1 mRNA)	TTELIN2	PTN1_HUMAN	Inhibitor	[2]

References

• [1] Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystal... J Med Chem. 2008 Jun 26;51(12):3540-54.
• [2] Triterpenoids from the leaves of Diospyros kaki (persimmon) and their inhibitory effects on protein tyrosine phosphatase 1B. J Nat Prod. 2008 Oct;71(10):1775-8.
• [3] Periodinates: a new class of protein tyrosine phosphatase inhibitors. Bioorg Med Chem Lett. 1999 Feb 8;9(3):353-6.
• [4] Evans Blue and other dyes as protein tyrosine phosphatase inhibitors. Bioorg Med Chem Lett. 2004 Apr 19;14(8):1923-6.
• [5] Cytotoxic and PTP1B inhibitory activities from Erythrina abyssinica. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6745-9.
• [6] Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2009).
• [7] Clinical pipeline report, company report or official report of ISIS Pharmaceuticals.
• [8] 2-O-carboxymethylpyrogallol derivatives as PTP1B inhibitors with antihyperglycemic activity. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5357-60.
• [9] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [10] Synthesis of 3-deoxypentacyclic triterpene derivatives as inhibitors of glycogen phosphorylase. J Nat Prod. 2009 Aug;72(8):1414-8.
• [11] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026877)
• [12] The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.