General Information of Drug (ID: DMYVP5G)

Drug Name
Insulin recombinant Drug Info
Synonyms
9004-10-8; Exubera; Insulin recombinant; Endopancrine; Humilin; Dermulin; Decurvon; Musulin; Iszilin; Insulyl; Insular; Iletin; insulin-human; Dal-insulinum; Intesulin B; Insulin, dalanated; Insulina dalanatada; AERx; Insulinum dalanatum; insulin (recombinant); Imusay-131; INSULIN INJECTION; Insulini injectio neutralis; Insulina iniettabile neutra; Injectable insulini neutrale; Inyectable neutro de insulina; CHEBI:5931; CCRIS 5464; Insulinum dalanatum [INN-Latin]; HSDB 3102; Insulin, dalanated [USAN:INN]; AERx [Insulin management system]
Indication
Disease Entry ICD 11 Status REF
Diabetic complication 5A2Y Approved [1]
Therapeutic Class
Hypoglycemic Agents
Cross-matching ID
PubChem CID
70678557
CAS Number
CAS 9004-10-8
TTD Drug ID
DMYVP5G
VARIDT Drug ID
DR00408

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug(s) Targeting Insulin receptor (INSR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Meglitinides DM1OFHN Type-2 diabetes 5A11 Approved [3]
Human neutral insulin DMA5OBU Diabetic complication 5A2Y Approved [2]
Insulin Lyspro recombinant DM5XHVR Diabetic complication 5A2Y Approved [2]
Insulin, porcine DMO95XI Diabetic complication 5A2Y Approved [4]
Metformin arginine-hemisuccinimide DMTPAM3 Type-2 diabetes 5A11 Approved [5]
Insulin-lispro DM4O90W Diabetic complication 5A2Y Approved [6]
Insulin-glulisine DMQI0FU Diabetic complication 5A2Y Approved [7]
Ryzodeq DMOFP18 Type-2 diabetes 5A11 Approved [8]
NN5401 DM0QV27 Diabetic complication 5A2Y Phase 3 [8]
Metformin glycinate DMFE0P1 Type-2 diabetes 5A11 Phase 2/3 [9]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Insulin receptor (INSR) TTCBFJO INSR_HUMAN Binder [2]

References

1 Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77.
2 Knockouts model the 100 best-selling drugs--will they model the next 100 Nat Rev Drug Discov. 2003 Jan;2(1):38-51.
3 New drugs for type 2 diabetes mellitus: what is their place in therapy Drugs. 2008;68(15):2131-62.
4 Acidic residues on the N-terminus of proinsulin C-Peptide are important for the folding of insulin precursor. J Biochem. 2002 Jun;131(6):855-9.
5 Metformin (Glucophage) inhibits tyrosine phosphatase activity to stimulate the insulin receptor tyrosine kinase. Biochem Pharmacol. 2004 Jun 1;67(11):2081-91.
6 Hope for insulin mimetic oral antidiabetic drugs. Eur J Endocrinol. 1999 Dec;141(6):561-2.
7 Insulin glulisine: a review of its use in the management of diabetes mellitus. Drugs. 2009;69(8):1035-57.
8 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1800).
9 Effect of Metformin Glycinate on Glycated Hemoglobin A1c Concentration and Insulin Sensitivity in Drug-Naive Adult Patients with Type 2 Diabetes Mellitus. Diabetes Technol Ther. 2012 December; 14(12): 1140-1144.