Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZ763A)

Drug Name
Autologous T Cells Expressing MET scFv CAR Drug Info
Indication
Disease Entry ICD 11 Status REF
Melanoma 2C30 Phase 1 [1]
Breast cancer 2C60-2C65 Phase 0 [1]
Cross-matching ID
TTD Drug ID
DMZ763A

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Proto-oncogene c-Met (MET)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [2]
Cabozantinib DMIYDT4 Medullary thyroid gland carcinoma Approved [3]
Amivantamab DMZ7AMY Non-small-cell lung cancer 2C25 Approved [4]
Capmatinib DMYCXKL Non-small-cell lung cancer 2C25.Y Approved [5]
Tepotinib DMUQ0E8 Non-small-cell lung cancer 2C25 Approved [6]
RG3638 DMTQJE0 Gastric adenocarcinoma 2B72 Phase 3 [7]
Savolitinib DMALFKX Renal cell carcinoma 2C90 Phase 3 [8]
Beperminogene perplasmid DM6RWBN Critical limb ischemia BD4Y Phase 3 [9]
Tivantinib DMNVP8Q Hepatocellular carcinoma 2C12.02 Phase 3 [10]
MGCD516 DM752PU Solid tumour/cancer 2A00-2F9Z Phase 2/3 [7]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Proto-oncogene c-Met (MET) TTNDSF4 MET_HUMAN CAR-T-Cell-Therapy [1]

References

1 ClinicalTrials.gov (NCT03060356) Autologous T Cells Expressing MET scFv CAR (RNA CART-cMET)
2 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
3 Clinical pipeline report, company report or official report of Exelixis (2011).
4 Antitumor Activity of Amivantamab (JNJ-61186372), an EGFR-MET Bispecific Antibody, in Diverse Models of EGFR Exon 20 Insertion-Driven NSCLC. Cancer Discov. 2020 Aug;10(8):1194-1209.
5 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020
6 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2021
7 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1815).
8 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
9 Beperminogene perplasmid for the treatment of critical limb ischemia. Expert Rev Cardiovasc Ther. 2014 Oct;12(10):1145-56.
10 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7948).