Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZ9BO8)

Drug Name

SR9011 Drug Info

Synonyms

SR-9011; 1379686-29-9; CHEMBL1961797; 3-[[(4-chlorophenyl)methyl-[(5-nitrothiophen-2-yl)methyl]amino]methyl]-N-pentylpyrrolidine-1-carboxamide; 1-Pyrrolidinecarboxamide, 3-((((4-chlorophenyl)methyl)((5-nitro-2-thienyl)methyl)amino)methyl)-n-pentyl-; GTPL8900; BDBM50366239; CS-4668; DB14014; SB19005; SR 9011; NCGC00347956-01; AK547296; AS-55867; HY-16988; Q15410183

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Preclinical	[1]

Cross-matching ID

PubChem CID: 57394021
CAS Number: CAS 1379686-29-9
TTD Drug ID: DMZ9BO8

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Preclinical Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting V-erbA-related protein 1 (NR1D1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GSK4112	DM1S5UO	Inflammation	1A00-CA43.1	Preclinical	[3]
SR8278	DMSK5N3	Myocardial disease	BC43.20	Preclinical	[3]
SR9009	DM8SKU1	Solid tumour/cancer	2A00-2F9Z	Preclinical	[2]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
V-erbA-related protein 1 (NR1D1)	TTAD1O8	NR1D1_HUMAN	Agonist	[2]

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References

1	Circadian rhythm as a therapeutic target. Nat Rev Drug Discov. 2021 Apr;20(4):287-307.
2	Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence. Nature. 2018 Jan 18;553(7688):351-355.
3	Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB. ACS Chem Biol. 2011 Feb 18;6(2):131-4.