General Information of Drug (ID: DMZGFE8)

Drug Name
PTR-3046 Drug Info
Synonyms CHEMBL439096
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
71717867
TTD Drug ID
DMZGFE8

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pasireotide DMHM7JS Cushing disease 5A70 Approved [2]
ODT-8 DMBWO5T N. A. N. A. Phase 3 [3]
FR-121196 DMNRUGA Alzheimer disease 8A20 Terminated [4]
SOMATOSTATIN DMIOFQE Acromegaly 5A60.0 Investigative [5]
Des-AA1,2,5-[D-Trp8,Tyr11]SRIF DM7MZ2V Discovery agent N.A. Investigative [6]
Des-AA1,2,5,12,13-[D-Trp8]SRIF DM1KJAE Discovery agent N.A. Investigative [3]
SRIF-28 DM0OM9L Discovery agent N.A. Investigative [7]
99mTc-MIP-1407 DMYPD5L Neuroendocrine cancer 2B72.1 Investigative [2]
Des-AA1,2,4,12,13-[D-Trp8]SRIF DMMWDC5 Discovery agent N.A. Investigative [3]
Cytotoxin Peptide Conjugate DM7SVLZ Discovery agent N.A. Investigative [8]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Somatostatin receptor type 5 (SSTR5) TT2BC4G SSR5_HUMAN Inhibitor [1]

References

1 Highly potent 4-amino-indolo[2,3-c]azepin-3-one-containing somatostatin mimetics with a range of sst receptor selectivities. J Med Chem. 2009 Jan 8;52(1):95-104.
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 359).
3 Somatostatin receptor 1 selective analogues: 3. Dicyclic peptides. J Med Chem. 2005 Jan 27;48(2):515-22.
4 Role of somatostatin in the augmentation of hippocampal long-term potentiation by FR121196, a putative cognitive enhancer. Eur J Pharmacol. 1993 Sep 7;241(1):27-34.
5 Discovery of iodinated somatostatin analogues selective for hsst2 and hsst5 with excellent inhibition of growth hormone and prolactin release from ... J Med Chem. 2005 Oct 20;48(21):6643-52.
6 Somatostatin receptor 1 selective analogues: 2. N(alpha)-Methylated scan. J Med Chem. 2005 Jan 27;48(2):507-14.
7 Novel octreotide dicarba-analogues with high affinity and different selectivity for somatostatin receptors. J Med Chem. 2010 Aug 26;53(16):6188-97.
8 An adjustable release rate linking strategy for cytotoxin-peptide conjugates. Bioorg Med Chem Lett. 2003 Mar 10;13(5):799-803.