Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZJH23)

Drug Name

REP8839 Drug Info

Synonyms

REP-8839; SB-682150; 2-[3-[4-Bromo-5-(1-fluorovinyl)-3-methylthien-2-ylmethylamino]propylamino]quinolin-4(1H)-one

Indication

Disease Entry	ICD 11	Status	REF
Bacterial infection	1A00-1C4Z	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting Streptococcus Methionyl-tRNA synthetase (Stre-coc metG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Difluoromethionine	DM8TG41	Discovery agent	N.A.	Investigative	[2]
5'-O-[(L-Methionyl)-Sulphamoyl]Adenosine	DM20X8C	Discovery agent	N.A.	Investigative	[2]
Methionine Phosphonate	DMOUTNA	Discovery agent	N.A.	Investigative	[2]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Streptococcus Methionyl-tRNA synthetase (Stre-coc metG)	TTOJ46K	SYM_STRP1	Inhibitor	[1]

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References

1	Antibacterial activity of REP8839, a new antibiotic for topical use. Antimicrob Agents Chemother. 2005 Oct;49(10):4247-52.
2	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.