Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZQXLS)

Drug Name

N-Trimethyllysine Drug Info

Synonyms

N-TRIMETHYLLYSINE; Trimethyllysine; epsilon-Trimethyllysine; N(epsilon)-Trimethyllysine; epsilon-Trimethyl-L-lysine; epsilon-N-Trimethyl-L-lysine; UNII-3YGF0495O2; CHEBI:17311; 3YGF0495O2; (S)-5-Amino-5-carboxy-N,N,N-trimethyl-1-pentanaminium; 19253-88-4; 1-Pentanaminium, 5-amino-5-carboxy-N,N,N-trimethyl-, (S)-; M3L; (S)-2-amino-6-(trimethylammonio)hexanoic acid; N-N-N-Trimethyllysine; N-epsilon-trimethyllysine; epsilon-N-Trimethyllysine; AC1L98PV; SCHEMBL181192; CHEMBL1234168; MXNRLFUSFKVQSK-QMMMGPOBSA-O; ZINC1529747

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 440121
ChEBI ID: CHEBI:17311
CAS Number: CAS 19253-88-4
TTD Drug ID: DMZQXLS

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Calmodulin (CALM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Halofantrine	DMOMK1V	Malaria	1F40-1F45	Approved	[2]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[3]
Aprindine	DMBXWU8	Cardiac arrhythmias	BC9Z	Approved	[4]
Acetate Ion	DMD08RH	Discovery agent	N.A.	Investigative	[1]
2-Methyl-2,4-Pentanediol	DMD45CU	Discovery agent	N.A.	Investigative	[1]
MYRISTIC ACID	DMYX0BL	Discovery agent	N.A.	Investigative	[5]
Cacodylate Ion	DMK4XLD	Discovery agent	N.A.	Investigative	[1]
2-Methyl-2-Propanol	DMHM5GJ	Discovery agent	N.A.	Investigative	[1]
Calmidazolium	DM5ZTJL	Huntington disease	8A01.10	Investigative	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Calmodulin (CALM)	TTV3NH6	CALM1_HUMAN; CALM2_HUMAN; CALM3_HUMAN	Inhibitor	[1]

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References

1	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
3	Inhibitory effect of jujuboside A on glutamate-mediated excitatory signal pathway in hippocampus. Planta Med. 2003 Aug;69(8):692-5.
4	Aprindine inhibits calmodulin-stimulated phosphodiesterase and Ca-ATPase activities. J Cardiovasc Pharmacol. 1983 Jan-Feb;5(1):151-6.
5	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
6	Calmidazolium evokes high calcium fluctuations in Plasmodium falciparum. Cell Signal. 2016 Mar;28(3):125-135.