General Information of Drug (ID: DMZUA5C)

Drug Name
MK-6302 Drug Info
Synonyms INS-20; Pegylated GCSF, Insmed/Merck
Indication
Disease Entry ICD 11 Status REF
Neutropenia 4B00.0 Phase 1 [1]
Cross-matching ID
TTD Drug ID
DMZUA5C

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tbo-Filgrastim DML6OE7 Neutropenia 4B00.0 Approved [3]
Pegfilgrastim DM7UP8X Central nervous system neoplasm Approved [4]
Peg-G-CSF DMBKWAF Solid tumour/cancer 2A00-2F9Z Phase 3 [5]
BLZ-945 DMG1LVA Amyotrophic lateral sclerosis 8B60.0 Phase 2 [5]
SBC-014 DMG1VXR Neutropenia 4B00.0 Phase 2 [6]
AX-200 DMTAEMB Cardiovascular disease BA00-BE2Z Phase 2 [7]
MAXY-G34 DMWLIPJ Neutropenia 4B00.0 Phase 2 [8]
PLX7486 DM0IVGU Pancreatic cancer 2C10 Phase 1 [9]
AMG 820 DMB6Q19 Solid tumour/cancer 2A00-2F9Z Phase 1 [10]
PLX-5622 DMK4PWM Autoimmune diabetes 5A10 Phase 1 [11]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Granulocyte colony-stimulating factor receptor (G-CSF-R) TTC70AJ CSF3R_HUMAN Modulator [2]

References

1 Clinical pipeline report, company report or official report of Merck.
2 Merck ditches biogeneric. Nat Biotechnol. 2010 Jul;28(7):636.
3 Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
4 Evidence that the granulocyte colony-stimulating factor (G-CSF) receptor plays a role in the pharmacokinetics of G-CSF and PegG-CSF using a G-CSF-R KO model. Pharmacol Res. 2004 Jul;50(1):55-8.
5 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1719).
6 A glycosylated recombinant human granulocyte colony stimulating factor produced in a novel protein production system (AVI-014) in healthy subjects: a first-in human, single dose, controlled study. BMC Clin Pharmacol. 2009; 9: 2.
7 Granulocyte colony-stimulating factor in patients with acute ischemic stroke: results of the AX200 for Ischemic Stroke trial. Stroke. 2013 Oct;44(10):2681-7.
8 Survival efficacy of the PEGylated G-CSFs Maxy-G34 and neulasta in a mouse model of lethal H-ARS, and residual bone marrow damage in treated survivors. Health Phys. 2014 Jan;106(1):21-38.
9 National Cancer Institute Drug Dictionary (drug id 747694).
10 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
11 Microglial Stimulation of Glioblastoma Invasion Involves Epidermal Growth Factor Receptor (EGFR) and Colony Stimulating Factor 1 Receptor (CSF-1R) Signaling. Mol Med. 2012; 18(1): 519-527.