Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZUNJ4)

Drug Name
US8933095, 14 Drug Info
Synonyms CHEMBL2347108; SCHEMBL9280114; BDBM107730; US8933095, 14
Cross-matching ID
PubChem CID
67813781
TTD Drug ID
DMZUNJ4

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Patented Agent(s)
Preclinical Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Kynurenine oxoglutarate transaminase II (AADAT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
US10065972, Example 560 DM9QCTJ N. A. N. A. Patented [2]
US8933095, 1 DMG3T7E N. A. N. A. Patented [3]
US10065972, Example 281 DMBWJK4 N. A. N. A. Patented [2]
US8933095, 16 DMRN5F4 N. A. N. A. Patented [3]
US10065972, Example 396 DMT8WVZ N. A. N. A. Patented [2]
US8933095, 18 DMOZ4FS N. A. N. A. Patented [1]
PF-04859989 DM3U2S5 Cognitive impairment 6D71 Preclinical [4]
BFF-122 DM6BGJ9 Cognitive impairment 6D71 Preclinical [5]
(S)-4-(Ethylsulfonyl)benzoylalanine DMEJYV4 Cognitive impairment 6D71 Preclinical [6]
⏷ Show the Full List of 9 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Kynurenine oxoglutarate transaminase II (AADAT) TTT3IXG AADAT_HUMAN Inhibitor [1]

References

1 KAT II inhibitors. US8598200.
2 Bicyclic or tricyclic heterocyclic compound. US10065972.
3 KAT II inhibitors. US8933095.
4 Investigating KYNA production and kynurenergic manipulation on acute mouse brain slice preparations. Brain Res Bull. 2019 Mar;146:185-191.
5 Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond. Nat Rev Drug Discov. 2019 May;18(5):379-401.
6 Specific inhibition of kynurenate synthesis enhances extracellular dopamine levels in the rodent striatum. Neuroscience. 2009 Mar 3;159(1):196-203.