Details of the Drug Reposition

General Information of This Drug (ID: DM6WPIS)

• Drug Name: L-serine (DM6WPIS)
• Synonyms: L-serine; serine; 56-45-1; (S)-2-Amino-3-hydroxypropanoic acid; H-Ser-OH; (S)-Serine; beta-Hydroxyalanine; L-ser; L-(-)-Serine; Polyserine; Serine, L-; (2S)-2-amino-3-hydroxypropanoic acid; L-3-Hydroxy-alanine; Poly-L-serine; 2-Amino-3-hydroxypropionic acid; beta-Hydroxy-L-alanine; Serinum [Latin]; Serina [Spanish]; L-2-Amino-3-hydroxypropionic acid; Serine (VAN); L-3-Hydroxy-2-aminopropionic acid; Serine [USAN:INN]; SER (IUPAC abbrev); 3-Hydroxyalanine; L-Serin; (S)-(-)-Serine; (-)-Serine; alpha-Amino-beta-hydroxypropionic acid
• Drug Type: Small molecular drug

Information on Drug Reposition of This Drug

2 Approved Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Pulmonary tuberculosis	DIS6FLUM	1B10.Z	Approved	[1]
Discovery agent	DISC7DFA	N.A.	Approved	[2]

1 Discontinued in Phase 3 Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Open-angle glaucoma	DISSZEE8	9C61	Discontinued in Phase 3	[3]

1 Discontinued in Phase 2 Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Bacterial urinary tract infection	DISNNJTF	N.A.	Discontinued in Phase 2	[4]

References

• [1] Heterologous production of the D-cycloserine intermediate O-acetyl-L-serine in a human type II pulmonary cell model. Sci Rep. 2023 May 26;13(1):8551.
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 726).
• [3] Study to Assess the Efficacy and Safety of LX201 for Prevention of Corneal Allograft Rejection Episodes and Graft Failure in Subjects at Increased Immunological Risk
• [4] ClinicalTrials.gov (NCT01368263) Goserelin and Letrozole or Anastrozole in Premenopausal Patients With Stage II-III Estrogen Receptor-Positive Breast Cancer