Details of the Drug

General Information of Drug (ID: DM6WPIS)

Drug Name

L-serine

Synonyms

L-serine; serine; 56-45-1; (S)-2-Amino-3-hydroxypropanoic acid; H-Ser-OH; (S)-Serine; beta-Hydroxyalanine; L-ser; L-(-)-Serine; Polyserine; Serine, L-; (2S)-2-amino-3-hydroxypropanoic acid; L-3-Hydroxy-alanine; Poly-L-serine; 2-Amino-3-hydroxypropionic acid; beta-Hydroxy-L-alanine; Serinum [Latin]; Serina [Spanish]; L-2-Amino-3-hydroxypropionic acid; Serine (VAN); L-3-Hydroxy-2-aminopropionic acid; Serine [USAN:INN]; SER (IUPAC abbrev); 3-Hydroxyalanine; L-Serin; (S)-(-)-Serine; (-)-Serine; alpha-Amino-beta-hydroxypropionic acid

Indication

Disease Entry	ICD 11	Status	REF
Pulmonary tuberculosis	1B10.Z	Approved	[1]
Discovery agent	N.A.	Investigative	[2]
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Drug Type

Small molecular drug

Structure

3D MOL is unavailable

2D MOL

#Ro5 Violations (Lipinski): 1

Molecular Weight (mw)

105.09

Logarithm of the Partition Coefficient (xlogp)

-3.1

Rotatable Bond Count (rotbonds)

Hydrogen Bond Donor Count (hbonddonor)

Hydrogen Bond Acceptor Count (hbondacc)

Chemical Identifiers

Formula: C3H7NO3
IUPAC Name: (2S)-2-amino-3-hydroxypropanoic acid
Canonical SMILES: C([C@@H](C(=O)O)N)O
InChI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1
InChIKey: MTCFGRXMJLQNBG-REOHCLBHSA-N

Cross-matching ID

PubChem CID: 5951
ChEBI ID: CHEBI:17115
CAS Number: 56-45-1
DrugBank ID: DB00133
TTD ID: D0T6GM
VARIDT ID: DR01005

Repurposed Drugs (RPD)

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Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
G-protein coupled receptor GPCR33 (GPRC6A)	TTI1PRE	GPC6A_HUMAN	Agonist	[3]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[4]
Ataxin-3 (ATXN3)	OTJVVGKT	ATX3_HUMAN	Gene/Protein Processing	[4]
Calnexin (CANX)	OTYP1F6J	CALX_HUMAN	Gene/Protein Processing	[4]
Calreticulin (CALR)	OTYD2TR1	CALR_HUMAN	Gene/Protein Processing	[4]
CCAAT/enhancer-binding protein beta (CEBPB)	OTM9MQIA	CEBPB_HUMAN	Gene/Protein Processing	[4]
Cyclic AMP-dependent transcription factor ATF-4 (ATF4)	OTRFV19J	ATF4_HUMAN	Gene/Protein Processing	[4]
Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6)	OTAFHAVI	ATF6A_HUMAN	Gene/Protein Processing	[4]
Cyclic AMP-dependent transcription factor ATF-6 beta (ATF6B)	OTT2ZGSR	ATF6B_HUMAN	Gene/Protein Processing	[4]
Derlin-2 (DERL2)	OTI3TUUZ	DERL2_HUMAN	Gene/Protein Processing	[4]
DnaJ homolog subfamily B member 2 (DNAJB2)	OTZHPV5M	DNJB2_HUMAN	Gene/Protein Processing	[4]

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Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	Heterologous production of the D-cycloserine intermediate O-acetyl-L-serine in a human type II pulmonary cell model. Sci Rep. 2023 May 26;13(1):8551.
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 726).
3	Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids. Mol Pharmacol. 2005 Mar;67(3):589-97.
4	Mechanisms of L-Serine Neuroprotection in vitro Include ER Proteostasis Regulation. Neurotox Res. 2018 Jan;33(1):123-132. doi: 10.1007/s12640-017-9829-3. Epub 2017 Nov 2.