Details of the Drug Reposition

General Information of This Drug (ID: DM7OKQV)

• Drug Name: Cholic Acid (DM7OKQV)
• Synonyms: cholic acid; 81-25-4; Cholalic acid; cholate; Cholalin; Colalin; Cholsaeure; NSC-6135; Cholic acid, 5beta-; 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanic acid; 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholan-24-oic acid; UNII-G1JO7801AE; HSDB 982; (R)-4-((3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid; Cholic acid [USAN]; 3,7,12-Trihydroxycholanic acid; G1JO7801AE; CHEMBL205596; CHEBI:16359; NSC6135; BHQCQFFYRZLCQQ-OELDTZBJSA-N
• Drug Type: Small molecular drug

Information on Drug Reposition of This Drug

3 Approved Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Synthesis disorder	DISJ3NWT	5C52-5C59	Approved	[1]
Peroxisomal disorder	DISV185U	5C57	Approved	[1]
Cholelithiasis	DISERLZB	DC11	Approved	[2]

3 Discontinued in Phase 3 Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Biliary tract disorder	DISNBDRC	N.A.	Discontinued in Phase 3	[3]
Cerebrotendinous xanthomatosis	DIST9FNK	N.A.	Discontinued in Phase 3	[4]
Constipation	DISRQXWI	DD91.1	Discontinued in Phase 3	[5]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 609).
• [2] Cholic acid FDA Label
• [3] ClinicalTrials.gov (NCT00642694) Time to Remission of Depressive Symptoms With Combined SSRI and Ramelteon
• [4] ClinicalTrials.gov (NCT00430937) Efficacy and Safety of Daptomycin Versus Vancomycin or Teicoplanin for Treatment of Complicated Skin and Soft Tissue Infections
• [5] Trial Comparing the Effects of Aripiprazole With Those of Standard of Care on Non-HDL Cholesterol in Patients With Schizophrenia or Bipolar I Disorder Who Have Metabolic Syndrome