Details of the Drug Reposition | DrugMAP

General Information of This Drug (ID: DM7UP8X)

Drug Name	Pegfilgrastim DM7UP8X
Synonyms	Neulasta; Neulasta (TN); Pegfilgrastim (INN)
Therapeutic Class	Immunomodulatory Agents
Drug Type	Small molecular drug
Structure
Structure	3D MOL is unavailable			2D MOL

Information on Drug Reposition of This Drug

Molecular Interaction Atlas (MIA)

10 Approved Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Central nervous system neoplasm	DISFC18W	N.A.	Approved	[1]
Splenic marginal zone lymphoma	DISCGTZY	N.A.	Approved	[2]
MALT lymphoma	DIS1AVVE	N.A.	Approved	[2]
Hemoglobinopathy	DISCT4GX	N.A.	Approved	[2]
Malignant solid tumour	DISITUVU	2C10-2F32	Approved	[3]
Lymphoma	DISN6V4S	2A80-2A86	Approved	[4]
Plasma cell myeloma	DIS0DFZ0	2A83.1	Approved	[5]
Nodal marginal zone lymphoma	DIS7MP4T	2A85.0	Approved	[2]
Non-small-cell lung cancer	DIS5Y6R9	2C25.Y	Approved	[6]
Thalassemia	DIS76XZB	3A50	Approved	[7]
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⏷ Show the Full List of 10 Indications(s)

References

1	Pegfilgrastim-induced hyperleukocytosis. Ann Pharmacother. 2007 Sep;41(9):1524-30.
2	A standard database for drug repositioning. Sci Data. 2017 Mar 14;4:170029.
3	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6969).
4	Feasibility and efficacy of low-dose pegfilgrastim for CD34(+) cell mobilization in lymphoma. J Clin Apher. 2020 Sep;35(5):413-419.
5	Effectiveness of biosimilar pegfilgrastim in patients with multiple myeloma after high-dose melphalan and autologous stem cell transplantation. Ann Hematol. 2023 Jul;102(7):1915-1925.
6	Efficacy and safety of second-line therapy of docetaxel plus ramucirumab after first-line platinum-based chemotherapy plus immune checkpoint inhibitors in non-small cell lung cancer (SCORPION): a multicenter, open-label, single-arm, phase 2 trial. EClinicalMedicine. 2023 Nov 10;66:102303.
7	Evaluating the safety and effectiveness of PegaGen(?) (pegfilgrastim) for the prevention of chemotherapy-induced febrile neutropenia: a post-marketing surveillance study. Support Care Cancer. 2022 Oct;30(10):8151-8158.