Details of the Drug Reposition | DrugMAP

General Information of This Drug (ID: DMC8UPL)

Drug Name	ION532 DMC8UPL
Synonyms	AZD2373
Drug Type	Antisense oligonucleotide

Information on Drug Reposition of This Drug

Molecular Interaction Atlas (MIA)

2 Phase 1 Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Chronic kidney disease	DISW82R7	GB61	Phase 1	[1]
Nephropathy	DISXWP4P	GC2Z	Phase 1	[2]
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References

1	ClinicalTrials.gov (NCT05351047) A Phase I, Randomized, Single-blind, Placebo-controlled Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD2373 Following Multiple Ascending Dose Administration to Healthy Male Participants of Sub-Saharan West African Ancestry. U.S.National Institutes of Health.
2	ClinicalTrials.gov (NCT04269031) A Phase I, First-in-Human, Randomized, Single-blind, Placebo-controlled Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD2373 Following Single Ascending Dose Administrations to Healthy Male Subjects of African Ancestry. U.S.National Institutes of Health.