Details of the Drug Reposition

General Information of This Drug (ID: DMIWFRL)

Drug Name
Tolvaptan   DMIWFRL
Synonyms
Samsca; OPC 41061; Benzazepine derivative, 32; OPC-41061; Samsca (TN); N-[4-(7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl)-3-methylphenyl]-2-methylbenzamide; (-)-4'-((7-Chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl)-o-tolu-m-toluidide; 7-Chloro-5-hydroxy-1-(2-methyl-4-(2-methylbenzoylamino)benzoyl)2,3,4,5-tetrahydro-1H-1-benzazepine
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

Information on Drug Reposition of This Drug

Molecular Interaction Atlas (MIA)
2 Approved Indication(s)
Indication Name Indication ID ICD-11 Status REF
Hyponatraemia DISSEH6G 5C72 Approved [1]
Autosomal dominant polycystic kidney disease DISBHWUI GB81 Approved [2]
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1 Phase 3 Indication(s)
Indication Name Indication ID ICD-11 Status REF
Heart failure DISJW62S BD10-BD13 Phase 3 [1]
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1 Discontinued in Phase 1 Indication(s)
Indication Name Indication ID ICD-11 Status REF
Inappropriate ADH syndrome DISQ2U9O N.A. Discontinued in Phase 1 [3]
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1 Investigative Indication(s)
Indication Name Indication ID ICD-11 Status REF
Hypernatremia DISVIU5K 5C71 Investigative [2]
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References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2226).
2 Tolvaptan FDA Label
3 A Study of Robatumumab (SCH 717454, MK-7454) in Combination With Different Treatment Regimens in Pediatric Participants With Advanced Solid Tumors (P05883, MK-7454-006)