Details of the Drug Reposition | DrugMAP

General Information of This Drug (ID: DMTI8YE)

Drug Name	Bosutinib DMTI8YE
Synonyms	SKI 606; SKI606; Bosutinib (USAN); PF-5208763; SKI-606; Xy]-3-quinolinecarbonitrile; 4-((2,4-dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(4-methyl-1-piperazinyl)propoxy)-3-quinolinecarbonitrile; 4-((2,4-dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinoline-3-carbonitrile; 4-(2,4-dichloro-5-methoxyanilino)-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile; 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propo; 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile; Bosutinib (BCR-ABL inhibitor 3rd gen)
Therapeutic Class	Anticancer Agents
Drug Type	Small molecular drug
Structure
Structure	3D MOL			2D MOL

Information on Drug Reposition of This Drug

Molecular Interaction Atlas (MIA)

2 Approved Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Blast phase chronic myelogenous leukemia, BCR-ABL1 positive	DIS3KLUX	N.A.	Approved	[1]
Breast cancer	DIS7DPX1	2C60-2C65	Approved	[2]
------------------------------------------------------------------------------------

1 Discontinued in Phase 2 Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Leukemia, myeloid, accelerated-phase	DISNDQL5	N.A.	Discontinued in Phase 2	[3]
------------------------------------------------------------------------------------

References

1	Bosutinib FDA Label
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5710).
3	ClinicalTrials.gov (NCT00275262) A Study to Evaluate the Ability of Lupron Depot to Enhance Immune Function Following Bone Marrow Transplantation. U.S. National Institutes of Health.