Details of Disease | DrugMAP

General Information of Disease (ID: DISNDQL5)

Disease Name	Leukemia, myeloid, accelerated-phase
Synonyms	Aggressive-Phase CML; Myelogenous Leukemia, Chronic, Aggressive-Phase; Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Myeloid Leukemia, Chronic, Aggressive-Phase; Aggressive-Phase Chronic Myelocytic Leukemia; Leukemia, Myeloid, Aggressive-Phase; Leukemia, Myelogenous, Aggressive Phase; Aggressive-Phase Chronic Myelogenous Leukemia; Myelogenous Leukemia, Chronic, Aggressive Phase; Aggressive-Phase Chronic Myelocytic Leukaemia; Leukemia, Myelogenous, Aggressive-Phase; Accelerated Phase Chronic Granulocytic Leukaemia; CML AGGRESSIVE; Accelerated Phase Chronic Myelogenous Leukaemia; Accelerated Phase CML; Leukemia, Myeloid, Accelerated-Phase; Accelerated phase chronic myeloid leukaemia; Myeloid Leukemia, Chronic, Accelerated Phase; Leukemia, Myeloid, Accelerated Phase; Accelerated Phase Chronic Myelocytic Leukaemia; Accelerated phase chronic myeloid leukemia; Aggressive-Phase Chronic Myeloid Leukaemia; Aggressive-Phase Chronic Myelogenous Leukaemia; Accelerated Phase Chronic Myelogenous Leukemia; Accelerated Phase Chronic Granulocytic Leukemia; Accelerated Phase Chronic Myeloid Leukemia; CML ACCELERATED; Aggressive-Phase Chronic Myeloid Leukemia; Accelerated Phase Chronic Myeloid Leukaemia; Myeloid Leukemia, Chronic, Aggressive Phase; Accelerated Phase Chronic Myelocytic Leukemia; Myeloid Leukemia, Chronic, Accelerated-Phase
Definition	The phase of chronic myeloid leukemia following the chronic phase (leukemia, myeloid, chronic-phase), where there are increased systemic symptoms, worsening cytopenias, and refractory leukocytosis.
Disease Hierarchy	DIS0301E: Chronic myelogenous leukaemia DISNDQL5: Leukemia, myeloid, accelerated-phase
Disease Identifiers	MONDO ID MONDO_0021367 MESH ID D015465 UMLS CUI C0023472 MedGen ID 6059 SNOMED CT ID 413389003

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
BMI1	TTIPNSR	Strong	Biomarker	[1]
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This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
BCR	OTCN76C1	Strong	Altered Expression	[2]
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References

1	BMI1 reprogrammes histone acetylation and enhances c-fos pathway via directly binding to Zmym3 in malignant myeloid progression. J Cell Mol Med. 2014 Jun;18(6):1004-17. doi: 10.1111/jcmm.12246. Epub 2014 Feb 27.
2	Gadd45a deficiency accelerates BCR-ABL driven chronic myelogenous leukemia.Oncotarget. 2017 Feb 14;8(7):10809-10821. doi: 10.18632/oncotarget.14580.