Details of the Drug

General Information of Drug (ID: DM03O8T)

Drug Name

PSMA-VRP

Synonyms

Alphavirus vector vaccine (prostate cancer), Progenics/Cytogen; PSMA antigen vaccine (prostate cancer), PSMA Co LLC/AlphaVax;PSMA viral vector vaccine (prostate cancer), PSMA Co LLC/AlphaVax; PSMA viral vector vaccine (prostate cancer), Progenics/CYTOGEN; PSMA antigen vaccine (prostate cancer), CYTOGEN/Progenics/AlphaVax

Indication

Disease Entry	ICD 11	Status	REF
Prostate cancer	2C82.0	Phase 1	[1]
------------------------------------------------------------------------------------

Drug Type

Vaccine

Cross-matching ID

TTD ID: D07KHR

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glutamate carboxypeptidase II (GCPII)	TT9G4N0	FOLH1_HUMAN	Not Available	[2]

------------------------------------------------------------------------------------

Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

ICD Disease Classification

02 Neoplasm

Disease Class

ICD-11: 2C82 Prostate cancer

The Studied Tissue

Prostate

The Studied Disease

Prostate cancer [ICD-11:2C82]

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Glutamate carboxypeptidase II (GCPII)	DTT	FOLH1	1.40E-09	2.08	2.21

Molecular Expression Atlas (MEA)

MEA Detail

Jump to Detail Molecular Expression Atlas of This Drug

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800012200)
2	A phase I dose escalation trial of vaccine replicon particles (VRP) expressing prostate-specific membrane antigen (PSMA) in subjects with prostate cancer. Vaccine. 2013 Jan 30;31(6):943-9.