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ClinicalTrials.gov (NCT02147964) ITT-5 Mechanisms of Spermatogenesis. U.S. National Institutes of Health.
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ClinicalTrials.gov (NCT04382898) First-in-human, Dose Titration and Expansion Trial to Evaluate Safety, Immunogenicity and Preliminary Efficacy of W_pro1 (BNT112) Monotherapy and in Combination With Cemiplimab in Patients With Prostate Cancer. U.S.National Institutes of Health.
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ClinicalTrials.gov (NCT03592264) This Study is to Evaluate OBI-3424 Safe and Effective Treatment Dose in Subjects With Hepatocellular Carcinoma or Castrate Resistant Prostate Cancer. U.S. National Institutes of Health.
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ClinicalTrials.gov (NCT02423590) Study of Gemcitabine/Carboplatin First-line Chemotherapy +/- Apatorsen in Advanced Squamous Cell Lung Cancers. U.S. National Institutes of Health.
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ClinicalTrials.gov (NCT03414034) Onvansertib in Combination With Abiraterone and Prednisone in Adult Patients With Metastatic Castration-Resistant Prostate Cancer. U.S. National Institutes of Health.
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ClinicalTrials.gov (NCT00691132) Phenethyl Isothiocyanate in Preventing Lung Cancer in Smokers. U.S. National Institutes of Health.
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ClinicalTrials.gov (NCT04114825) Study of RV001V in Biochemical Failure Following Curatively Intended Therapy For Localized Prostate Cancer (BRaVac). U.S. National Institutes of Health.
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ClinicalTrials.gov (NCT05005728) Phase 2 Multiple-Dose, Multiple-Arm, Parallel Assignment Study to Evaluate the Safety, Tolerability, and Preliminary Efficacy of XmAb?20717 Alone or in Combination With Chemotherapy or Targeted Therapies in Selected Subjects With Metastatic Castration-Resistant Prostate Cancer. U.S.National Institutes of Health.
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ClinicalTrials.gov (NCT00050297) YM598 in Patients With Rising PSA After Initial Therapy for Localized Prostate Cancer. U.S. National Institutes of Health.
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ClinicalTrials.gov (NCT04471974) ZEN-3694, Enzalutamide, and Pembrolizumab for the Treatment of Metastatic Castration-Resistant Prostate Cancer. U.S. National Institutes of Health.
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ClinicalTrials.gov (NCT05156905) A Phase 1b Trial Investigating Docetaxel Combined With Cirmtuzumab in Patients With Metastatic Castration Resistant Prostate Cancer. U.S.National Institutes of Health.
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ClinicalTrials.gov (NCT03490838) 177Lu-PSMA-R2 in Patients With PSMA Positive Progressive, Metastatic, Castration Resistant Prostate Cancer (PROter). U.S. National Institutes of Health.
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ClinicalTrials.gov (NCT05249127) 64Cu-SAR-bisPSMA Positron Emission Tomography: A Phase 1/2 Study of Participants With Biochemical Recurrence of Prostate Cancer. U.S.National Institutes of Health.
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ClinicalTrials.gov (NCT04868604) A Phase I/IIa Theranostic Study of 64Cu-SAR-bisPSMA and 67Cu-SAR-bisPSMA for Identification and Treatment of PSMA-expressing Metastatic Castrate Resistant Prostate Cancer. U.S.National Institutes of Health.
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ClinicalTrials.gov (NCT04631601) A Master Protocol Evaluating the Safety and Efficacy of Therapies for Metastatic Castration-resistant Prostate Cancer (mCRPC). U.S.National Institutes of Health.
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ClinicalTrials.gov (NCT01862900) Stereotactic Body Radiation and Monoclonal Antibody to OX40 in Breast Cancer Patients With Metastatic Lesions. U.S. National Institutes of Health.
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ClinicalTrials.gov (NCT03888612) Trial of ARV-110 in Patients With Metastatic Castration Resistant Prostate Cancer (mCRPC). U.S. National Institutes of Health.
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ClinicalTrials.gov (NCT05067140) A Phase 1/2 Open-Label, Dose-Escalation and Cohort Expansion Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ARV-766 Monotherapy and in Combination With Abiraterone in Patients With Metastatic Prostate Cancer. U.S.National Institutes of Health.
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ClinicalTrials.gov (NCT01352208) Phase I/II Study of ASP9521 in Castrate-Resistant Prostate Cancer (CRPC) Patients. U.S. National Institutes of Health.
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ClinicalTrials.gov (NCT02744287) Use of Ligand-Inducible Autologous T Cells Engineered to Target PSCA on Tumor Cells in Selected Advanced Solid Tumors
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ClinicalTrials.gov (NCT03910660) Phase 1b/2 Study of BXCL701, a Small Molecule Inhibitor of Dipeptidyl Peptidases, Administered in Combination With the Anti-Programmed Cell Death 1 Monoclonal Antibody Pembrolizumab in Patients With mCRPC Either Small Cell Neuroendocrine Prostate Cancer or Adenocarcinoma Phenotype. U.S.National Institutes of Health.
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ClinicalTrials.gov (NCT03013712) A Clinical Research of CAR T Cells Targeting EpCAM Positive Cancer
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ClinicalTrials.gov (NCT01225471) Novel Peptide Vaccination for Patients With Advanced Prostate Cancer. U.S. National Institutes of Health.
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Recent progress in pharmaceutical therapies for castration-resistant prostate cancer. Int J Mol Sci. 2013 Jul 4;14(7):13958-78.
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ClinicalTrials.gov (NCT01171729) Autologous Dendritic Cell Therapy for Hormone-Refractory Metastatic Prostate Cancer. U.S. National Institutes of Health.
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ClinicalTrials.gov (NCT03300505) ARRO-CITO: (UMCC 2017.055) Phase Ib/II Single-Arm Multi-Center Study of IONIS-AR-2.5Rx, a Next Generation Androgen Receptor Antisense Oligonucleotide, in Combination With Enzalutamide in Metastatic Castration Resistant Prostate Cancer. U.S.National Institutes of Health.
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ClinicalTrials.gov (NCT05369000) Phase 1/2a Open-label Trial to Evaluate the Safety, Tolerability, PK, PD, Immunogenicity, and Antitumor Activity of LAVA-1207, a PSMA-targeting Bispecific gamma-delta-T Cell Engager, in Patients With Therapy Refractory mCRPC. U.S.National Institutes of Health.
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ClinicalTrials.gov (NCT03436485) Safety and Pharmacokinetics of ODM-208 in Patients With Metastatic Castration-resistant Prostate Cancer. U.S.National Institutes of Health.
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ClinicalTrials.gov (NCT00070837) MLN2704 in Subjects With Metastatic Androgen-Independent Prostate Cancer. U.S. National Institutes of Health.
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800039208)
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ClinicalTrials.gov (NCT00895466) Efficacy and Safety Study of the Therapeutic Vaccine PEP223 in Prostate Cancer Patients. U.S. National Institutes of Health.
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021046)
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ClinicalTrials.gov (NCT00859729) Dose Finding Study of a DNA Vaccine Delivered With Intradermal Electroporation in Patients With Prostate Cancer. U.S. National Institutes of Health.
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ClinicalTrials.gov (NCT05125016) Phase 1/2 Study of REGN4336 (a PSMAXCD3 Bispecific Antibody) Administered Alone or in Combination With Cemiplimab in Patients With Metastatic Castration-Resistant Prostate Cancer. U.S.National Institutes of Health.
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ClinicalTrials.gov (NCT03972657) Study of REGN5678 (Anti-PSMAxCD28) With Cemiplimab (Anti-PD-1) in Patients With Metastatic Castration-resistant Prostate Cancer. U.S. National Institutes of Health.
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ClinicalTrials.gov (NCT01931046) Study of a Recombinant Adenovirus to Treat Localized Prostate Cancer. U.S. National Institutes of Health.
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ClinicalTrials.gov (NCT03741712) A Study of SHR2554 Alone or in Combination With SHR3680 in the Treatment of mCRPC. U.S. National Institutes of Health.
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ClinicalTrials.gov (NCT05489991) A Phase 1/2, Open-label, Multi-Center Study of Dually Armored Chimeric Antigen Receptor (CAR) T-cells (TmPSMA-02) in Patients With Metastatic Castration Resistant Prostate Cancer (mCRPC). U.S.National Institutes of Health.
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ClinicalTrials.gov (NCT02987829) Phase 1/2A Study of TRC253, an Androgen Receptor Antagonist, in Metastatic Castration-resistant Prostate Cancer Patients. U.S. National Institutes of Health.
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ClinicalTrials.gov (NCT04843319) Open-Label, Proof-of-Concept and Dose Finding Phase 1b/2 Study of VERU-100 in Men With Advanced Prostate Cancer. U.S.National Institutes of Health.
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ClinicalTrials.gov (NCT03822871) A Trial of CTT1403 for Metastatic Castration Resistant Prostate Cancer. U.S. National Institutes of Health.
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ClinicalTrials.gov (NCT03276572) Phase I Dose-Escalation Trial of 225Ac-J591 in Patients With Metastatic Castration-Resistant Prostate Cancer. U.S.National Institutes of Health.
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ClinicalTrials.gov (NCT03724747) Study to Evaluate the Safety, Tolerability,Pharmacokinetics, and Antitumor Activity of a Thorium-227 Labeled Antibody-chelator Conjugate Alone and in Combination With Darolutamide, in Patients With Metastatic Castration Resistant Prostate Cancer. U.S. National Institutes of Health.
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The impact of germline genetic variations in hydroxysteroid (17-beta) dehydrogenases on prostate cancer outcomes after prostatectomy.Eur Urol. 2012 Jul;62(1):88-96. doi: 10.1016/j.eururo.2011.12.021. Epub 2011 Dec 21.
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Loss of prostatic acid phosphatase and -synuclein cause motor circuit degeneration without altering cerebellar patterning.PLoS One. 2019 Sep 11;14(9):e0222234. doi: 10.1371/journal.pone.0222234. eCollection 2019.
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Increased expression of EHF contributes to thyroid tumorigenesis through transcriptionally regulating HER2 and HER3.Oncotarget. 2016 Sep 6;7(36):57978-57990. doi: 10.18632/oncotarget.11154.
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A novel DNA methylation score accurately predicts death from prostate cancer in men with low to intermediate clinical risk factors.Oncotarget. 2016 Nov 1;7(44):71833-71840. doi: 10.18632/oncotarget.12377.
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NKAIN2 functions as a novel tumor suppressor in prostate cancer.Oncotarget. 2016 Sep 27;7(39):63793-63803. doi: 10.18632/oncotarget.11690.
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Constructing Bayesian networks by integrating gene expression and copy number data identifies NLGN4Y as a novel regulator of prostate cancer progression.Oncotarget. 2016 Oct 18;7(42):68688-68707. doi: 10.18632/oncotarget.11925.
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Aberrant methylation of PCDH10 predicts worse biochemical recurrence-free survival in patients with prostate cancer after radical prostatectomy.Med Sci Monit. 2014 Aug 3;20:1363-8. doi: 10.12659/MSM.891241.
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CD44 collaborates with ERBB2 mediate radiation resistance via p38 phosphorylation and DNA homologous recombination pathway in prostate cancer.Exp Cell Res. 2018 Sep 1;370(1):58-67. doi: 10.1016/j.yexcr.2018.06.006. Epub 2018 Jun 15.
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Upregulation of RASGRP3 expression in prostate cancer correlates with aggressive capabilities and predicts biochemical recurrence after radical prostatectomy.Prostate Cancer Prostatic Dis. 2014 Jun;17(2):119-25. doi: 10.1038/pcan.2013.51. Epub 2014 Jan 14.
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Role of RbBP5 and H3K4me3 in the vicinity of Snail transcription start site during epithelial-mesenchymal transition in prostate cancer cell.Oncotarget. 2016 Oct 4;7(40):65553-65567. doi: 10.18632/oncotarget.11549.
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miR-888 is an expressed prostatic secretions-derived microRNA that promotes prostate cell growth and migration.Cell Cycle. 2014;13(2):227-39. doi: 10.4161/cc.26984. Epub 2013 Nov 7.
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Identification of a novel fusion transcript between human relaxin-1 (RLN1) and human relaxin-2 (RLN2) in prostate cancer.Mol Cell Endocrinol. 2016 Jan 15;420:159-68. doi: 10.1016/j.mce.2015.10.011. Epub 2015 Oct 21.
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miR-375 induces docetaxel resistance in prostate cancer by targeting SEC23A and YAP1.Mol Cancer. 2016 Nov 10;15(1):70. doi: 10.1186/s12943-016-0556-9.
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Molecular cloning of canine co-chaperone small glutamine-rich tetratricopeptide repeat-containing protein (SGTA) and investigation of its ability to suppress androgen receptor signalling in androgen-independent prostate cancer.Vet J. 2015 Nov;206(2):143-8. doi: 10.1016/j.tvjl.2015.08.002. Epub 2015 Aug 7.
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The transcriptional co-activator SND1 is a novel regulator of alternative splicing in prostate cancer cells.Oncogene. 2014 Jul 17;33(29):3794-802. doi: 10.1038/onc.2013.360. Epub 2013 Sep 2.
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First-of-its-kind STARD(3) Inhibitor: In Silico Identification and Biological Evaluation as Anticancer Agent.ACS Med Chem Lett. 2019 Feb 20;10(4):475-480. doi: 10.1021/acsmedchemlett.8b00509. eCollection 2019 Apr 11.
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Steroid Receptor-Associated Immunophilins: Candidates for Diverse Drug-Targeting Approaches in Disease.Curr Mol Pharmacol. 2015;9(1):66-95. doi: 10.2174/1874467208666150519113639.
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TRIM29 as a novel prostate basal cell marker for diagnosis of prostate cancer.Acta Histochem. 2014 Jun;116(5):708-12. doi: 10.1016/j.acthis.2013.12.009. Epub 2014 Jan 30.
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