Details of the Drug

General Information of Drug (ID: DM15CJZ)

Drug Name

UCL-2138

Synonyms

UCL-2138; CHEMBL129257; 4-(3-piperidin-1-ylpropoxy)benzonitrile; Benzonitrile, 4-[3-(1-piperidinyl)propoxy]-; 146440-20-2; AC1MGZLJ; ACMC-20n4tz; SCHEMBL491825; GTPL1257; CTK0B2418; DTXSID60388154; UCL2138; ZINC2009079; UCL 2138; PDSP2_000689; BDBM50133003; PDSP1_000699; AKOS009440882; MCULE-6416627117; 4-[3-(1-Piperidinyl)propoxy]benzonitrile; 4-(3-Piperidin-1-yl-propoxy)-benzonitrile; 4-(3-(piperidin-1-yl)propoxy)benzonitrile

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

#Ro5 Violations (Lipinski): 0

Molecular Weight (mw)

244.33

Logarithm of the Partition Coefficient (xlogp)

2.9

Rotatable Bond Count (rotbonds)

5

Hydrogen Bond Donor Count (hbonddonor)

0

Hydrogen Bond Acceptor Count (hbondacc)

3

Chemical Identifiers

Formula: C15H20N2O
IUPAC Name: 4-(3-piperidin-1-ylpropoxy)benzonitrile
Canonical SMILES: C1CCN(CC1)CCCOC2=CC=C(C=C2)C#N
InChI: InChI=1S/C15H20N2O/c16-13-14-5-7-15(8-6-14)18-12-4-11-17-9-2-1-3-10-17/h5-8H,1-4,9-12H2
InChIKey: RHMNKKOAWUCDRK-UHFFFAOYSA-N

Cross-matching ID

PubChem CID: 2994072
CAS Number: 146440-20-2
TTD ID: D09ROG

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Histamine H3 receptor (H3R)	TT9JNIC	HRH3_HUMAN	Inhibitor	[2]

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Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Histamine H3 receptor (H3R)	DTT	HRH3	3.62E-02	-0.09	-0.22

Molecular Expression Atlas (MEA)

MEA Detail

Jump to Detail Molecular Expression Atlas of This Drug

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1257).
2	Fluorinated non-imidazole histamine H3 receptor antagonists. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2172-5.