Details of the Drug

General Information of Drug (ID: DM1FUAR)

Drug Name

MV-CEA

Synonyms

Measles virus derivative producing cea; Carcinoembryonic antigen-expressing measles virus (cancer), NCI; Mv-cea (ovarian and peritoneal cavity cancer), NCI

Indication

Disease Entry	ICD 11	Status	REF
Glioblastoma multiforme	2A00.0	Phase 1	[1]
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Cross-matching ID

TTD ID: D0U1WP

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Carcinoembryonic antigen CEA (CD66e)	TTY6DTE	CEAM5_HUMAN	Modulator	[1]

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Molecular Interaction Atlas (MIA)

MIA Detail

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Molecular Expression Atlas of This Drug

The Studied Disease

Glioblastoma multiforme

ICD Disease Classification

2A00.0

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Carcinoembryonic antigen CEA (CD66e)	DTT	CEACAM5	6.68E-91	0.29	1.07

Molecular Expression Atlas (MEA)

MEA Detail

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References

1	Phase I trial of intraperitoneal administration of an oncolytic measles virus strain engineered to express carcinoembryonic antigen for recurrent ovarian cancer. Cancer Res. 2010 Feb 1;70(3):875-82.