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ClinicalTrials.gov (NCT00519506) A Phase II Study to Evaluate the Efficacy of ThromboView in the Detection of Pulmonary Emboli. U.S. National Institutes of Health.
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ClinicalTrials.gov (NCT01124539) Study of AR-67 in Adult Patients With Recurrence of Glioblastoma Multiforme (GBM) or Gliosarcoma. U.S. National Institutes of Health.
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ClinicalTrials.gov (NCT01213407) Dendritic Cell Cancer Vaccine for High-grade Glioma. U.S. National Institutes of Health.
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ClinicalTrials.gov (NCT05053880) A Phase 1b/2a Study of ACT001 and Anti-PD-1 in Patients With Surgically Accessible Recurrent Glioblastoma Multiforme. U.S.National Institutes of Health.
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ClinicalTrials.gov (NCT03170141) Immunogene-modified T (IgT) Cells Against Glioblastoma Multiforme
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ClinicalTrials.gov (NCT01454596) CAR T Cell Receptor Immunotherapy Targeting EGFRvIII for Patients With Malignant Gliomas Expressing EGFRvIII. U.S. National Institutes of Health.
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800039199)
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ClinicalTrials.gov (NCT03296696) Study of AMG 596 in Patients With EGFRvIII Positive Glioblastoma. U.S. National Institutes of Health.
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ClinicalTrials.gov (NCT02844062) Pilot Study of Autologous Anti-EGFRvIII CAR T Cells in Recurrent Glioblastoma Multiforme
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ClinicalTrials.gov (NCT02937844) Pilot Study of Autologous Chimeric Switch Receptor Modified T Cells in Recurrent Glioblastoma Multiforme
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Clinical studies and trials in cancer. Malaghan Institute of Medical Research.
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ClinicalTrials.gov (NCT02664363) EGFRvIII CAR T Cells for Newly-Diagnosed WHO Grade IV Malignant Glioma
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A phase I clinical trial of interferon-beta gene therapy for high-grade glioma: novel findings from gene expression profiling and autopsy. J Gene Med. 2008 Apr;10(4):329-39.
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ClinicalTrials.gov (NCT01403285) Peptide-based Glioma Vaccine IMA950 in Patients With Glioblastoma. U.S. National Institutes of Health.
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ClinicalTrials.gov (NCT02326441) Safety, Tolerability & PK of KX2-361 in Subjects w Adv. Malignancies Refractory to Conventional Therapies. U.S. National Institutes of Health.
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ClinicalTrials.gov (NCT03696030) HER2-CAR T Cells in Treating Patients With Recurrent Brain or Leptomeningeal Metastases. U.S. National Institutes of Health.
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Therapeutic concentrations of anti-epileptic drugs do not inhibit the activity of the oncolytic adenovirus Delta24-RGD in malignant glioma. J Gene Med. 2013 Mar-Apr;15(3-4):134-41.
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Phase I trial of intraperitoneal administration of an oncolytic measles virus strain engineered to express carcinoembryonic antigen for recurrent ovarian cancer. Cancer Res. 2010 Feb 1;70(3):875-82.
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025449)
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URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4883).
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The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
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Inhibition of Acetyl-CoA Carboxylase 1 (ACC1) and 2 (ACC2) Reduces Proliferation and De Novo Lipogenesis of EGFRvIII Human Glioblastoma Cells.PLoS One. 2017 Jan 12;12(1):e0169566. doi: 10.1371/journal.pone.0169566. eCollection 2017.
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FoxM1 drives ADAM17/EGFR activation loop to promote mesenchymal transition in glioblastoma.Cell Death Dis. 2018 May 1;9(5):469. doi: 10.1038/s41419-018-0482-4.
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Matrix-degrading proteases ADAMTS4 and ADAMTS5 (disintegrins and metalloproteinases with thrombospondin motifs 4 and 5) are expressed in human glioblastomas.Int J Cancer. 2006 Jan 1;118(1):55-61. doi: 10.1002/ijc.21258.
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C1q/TNF-related peptide 8 (CTRP8) promotes temozolomide resistance in human glioblastoma.Mol Oncol. 2018 Sep;12(9):1464-1479. doi: 10.1002/1878-0261.12349. Epub 2018 Aug 2.
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The Mechanistic Role of the Calcium-Activated Chloride Channel ANO1 in Tumor Growth and Signaling.Adv Exp Med Biol. 2017;966:1-14. doi: 10.1007/5584_2016_201.
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Identification of blood biomarkers in glioblastoma by SWATH mass spectrometry and quantitative targeted absolute proteomics.PLoS One. 2018 Mar 7;13(3):e0193799. doi: 10.1371/journal.pone.0193799. eCollection 2018.
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In search of druggable targets for GBM amino acid metabolism.BMC Cancer. 2017 Feb 28;17(1):162. doi: 10.1186/s12885-017-3148-1.
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Regulation of Integrated Stress Response Sensitizes U87MG Glioblastoma Cells to Temozolomide Through the Mitochondrial Apoptosis Pathway.Anat Rec (Hoboken). 2018 Aug;301(8):1390-1397. doi: 10.1002/ar.23839. Epub 2018 May 13.
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High ATP2A2 expression correlates with better prognosis of diffuse astrocytic tumor patients.Oncol Rep. 2017 May;37(5):2865-2874. doi: 10.3892/or.2017.5528. Epub 2017 Mar 24.
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Multistage Ultraviolet Photodissociation Mass Spectrometry To Characterize Single Amino Acid Variants of Human Mitochondrial BCAT2.Anal Chem. 2018 Aug 21;90(16):9904-9911. doi: 10.1021/acs.analchem.8b02099. Epub 2018 Aug 1.
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The functional synergism of microRNA clustering provides therapeutically relevant epigenetic interference in glioblastoma.Nat Commun. 2019 Jan 25;10(1):442. doi: 10.1038/s41467-019-08390-z.
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A Novel Micro Cold Atmospheric Plasma Device for Glioblastoma Both In Vitro and In Vivo.Cancers (Basel). 2017 May 30;9(6):61. doi: 10.3390/cancers9060061.
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Disruption of the monocarboxylate transporter-4-basigin interaction inhibits the hypoxic response, proliferation, and tumor progression.Sci Rep. 2017 Jun 27;7(1):4292. doi: 10.1038/s41598-017-04612-w.
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Identification of hub genes and pathways in glioblastoma by bioinformatics analysis.Oncol Lett. 2019 Jan;17(1):1035-1041. doi: 10.3892/ol.2018.9644. Epub 2018 Oct 31.
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A positive feedback loop involving nuclear factor IB and calpain 1 suppresses glioblastoma cell migration.J Biol Chem. 2019 Aug 23;294(34):12638-12654. doi: 10.1074/jbc.RA119.008291. Epub 2019 Jul 1.
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Long non-coding RNA CASP5 promotes the malignant phenotypes of human glioblastoma multiforme.Biochem Biophys Res Commun. 2018 Jun 12;500(4):966-972. doi: 10.1016/j.bbrc.2018.04.217. Epub 2018 May 2.
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The prostanoid pathway contains potential prognostic markers for glioblastoma.Prostaglandins Other Lipid Mediat. 2018 Jul;137:52-62. doi: 10.1016/j.prostaglandins.2018.06.003. Epub 2018 Jun 30.
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Cytokine CCL5 and receptor CCR5 axis in glioblastoma multiforme.Radiol Oncol. 2019 Nov 20;53(4):397-406. doi: 10.2478/raon-2019-0057.
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Application of Neurokinin-1 Receptor in Targeted Strategies for Glioma Treatment. Part I: Synthesis and Evaluation of Substance P Fragments Labeled with (99m)Tc and (177)Lu as Potential Receptor Radiopharmaceuticals.Molecules. 2018 Oct 5;23(10):2542. doi: 10.3390/molecules23102542.
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Analysis of immunobiologic markers in primary and recurrent glioblastoma.J Neurooncol. 2018 Apr;137(2):249-257. doi: 10.1007/s11060-017-2732-1. Epub 2018 Jan 4.
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Effects of tumor grade and dexamethasone on myeloid cells in patients with glioma.Oncoimmunology. 2018 Aug 27;7(11):e1507668. doi: 10.1080/2162402X.2018.1507668. eCollection 2018.
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Temozolomide Treatment Induces lncRNA MALAT1 in an NF-B and p53 Codependent Manner in Glioblastoma.Cancer Res. 2019 May 15;79(10):2536-2548. doi: 10.1158/0008-5472.CAN-18-2170. Epub 2019 Apr 2.
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Poly(I:C) primes primary human glioblastoma cells for an immune response invigorated by PD-L1 blockade.Oncoimmunology. 2017 Dec 12;7(3):e1407899. doi: 10.1080/2162402X.2017.1407899. eCollection 2018.
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Identification of the potential oncogenes in glioblastoma based on bioinformatic analysis and elucidation of the underlying mechanisms.Oncol Rep. 2018 Aug;40(2):715-725. doi: 10.3892/or.2018.6483. Epub 2018 Jun 11.
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A Novel Small-Molecule Inhibitor of MRCK Prevents Radiation-Driven Invasion in Glioblastoma.Cancer Res. 2018 Nov 15;78(22):6509-6522. doi: 10.1158/0008-5472.CAN-18-1697. Epub 2018 Oct 2.
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CDC7-dependent transcriptional regulation of RAD54L is essential for tumorigenicity and radio-resistance of glioblastoma.Transl Oncol. 2018 Apr;11(2):300-306. doi: 10.1016/j.tranon.2018.01.003. Epub 2018 Feb 4.
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Myc targeted CDK18 promotes ATR and homologous recombination to mediate PARP inhibitor resistance in glioblastoma.Nat Commun. 2019 Jul 2;10(1):2910. doi: 10.1038/s41467-019-10993-5.
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The Chk1 inhibitor SAR-020106 sensitizes human glioblastoma cells to irradiation, to temozolomide, and to decitabine treatment.J Exp Clin Cancer Res. 2019 Oct 21;38(1):420. doi: 10.1186/s13046-019-1434-2.
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Alterations of the levels of primary antioxidant enzymes in different grades of human astrocytoma tissues.Free Radic Res. 2018 Aug;52(8):856-871. doi: 10.1080/10715762.2018.1483580.
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Casein Kinase 1 Epsilon Regulates Glioblastoma Cell Survival.Sci Rep. 2018 Sep 11;8(1):13621. doi: 10.1038/s41598-018-31864-x.
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Cathepsin B contributes to radioresistance by enhancing homologous recombination in glioblastoma.Biomed Pharmacother. 2018 Nov;107:390-396. doi: 10.1016/j.biopha.2018.08.007. Epub 2018 Aug 9.
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Detection of immune responses after immunotherapy in glioblastoma using PET and MRI.Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):10220-10225. doi: 10.1073/pnas.1706689114. Epub 2017 Sep 5.
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The synergistic effect of DZNEP, panobinostat and temozolomide reduces clonogenicity and induces apoptosis in glioblastoma cells.Int J Oncol. 2020 Jan;56(1):283-300. doi: 10.3892/ijo.2019.4905. Epub 2019 Oct 30.
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Targeting the mesenchymal subtype in glioblastoma and other cancers via inhibition of diacylglycerol kinase alpha.Neuro Oncol. 2018 Jan 22;20(2):192-202. doi: 10.1093/neuonc/nox119.
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miR-29s inhibit the malignant behavior of U87MG glioblastoma cell line by targeting DNMT3A and 3B.Neurosci Lett. 2015 Mar 17;590:40-6. doi: 10.1016/j.neulet.2015.01.060. Epub 2015 Jan 24.
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The Dopamine D2 Receptor Contributes to the Spheroid Formation Behavior of U87 Glioblastoma Cells.Pharmacology. 2020;105(1-2):19-27. doi: 10.1159/000502562. Epub 2019 Oct 23.
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MKP1 phosphatase is recruited by CXCL12 in glioblastoma cells and plays a role in DNA strand breaks repair.Carcinogenesis. 2020 Jun 17;41(4):417-429. doi: 10.1093/carcin/bgz151.
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Expression of endothelin-1 and endothelin receptors in cultured human glioblastoma cells.J Cardiovasc Pharmacol. 2000 Nov;36(5 Suppl 1):S390-2. doi: 10.1097/00005344-200036051-00113.
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Rottlerin inhibits cell growth and invasion via down-regulation of Cdc20 in glioma cells.Oncotarget. 2016 Oct 25;7(43):69770-69782. doi: 10.18632/oncotarget.11974.
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DNA Repair Capacity in Multiple Pathways Predicts Chemoresistance in Glioblastoma Multiforme.Cancer Res. 2017 Jan 1;77(1):198-206. doi: 10.1158/0008-5472.CAN-16-1151. Epub 2016 Oct 28.
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Interleukin-8/CXCR2 signaling regulates therapy-induced plasticity and enhances tumorigenicity in glioblastoma.Cell Death Dis. 2019 Mar 29;10(4):292. doi: 10.1038/s41419-019-1387-6.
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4-Hydroxy-7-oxo-5-heptenoic acid lactone is a potent inducer of brain cancer cell invasiveness that may contribute to the failure of anti-angiogenic therapies.Free Radic Biol Med. 2020 Jan;146:234-256. doi: 10.1016/j.freeradbiomed.2019.11.009. Epub 2019 Nov 9.
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FABP4 accelerates glioblastoma cell growth and metastasis through Wnt10b signalling.Eur Rev Med Pharmacol Sci. 2018 Nov;22(22):7807-7818. doi: 10.26355/eurrev_201811_16405.
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Delta-6-desaturase inhibitor enhances radiation therapy in glioblastoma in vitro and in vivo.Cancer Manag Res. 2018 Dec 7;10:6779-6790. doi: 10.2147/CMAR.S185601. eCollection 2018.
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IGFBP2 promotes immunosuppression associated with its mesenchymal induction and FcRIIB phosphorylation in glioblastoma.PLoS One. 2019 Sep 27;14(9):e0222999. doi: 10.1371/journal.pone.0222999. eCollection 2019.
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Toxic effects of phytol and retinol on human glioblastoma cells are associated with modulation of cholesterol and fatty acid biosynthetic pathways.J Neurooncol. 2018 Feb;136(3):435-443. doi: 10.1007/s11060-017-2672-9. Epub 2017 Nov 20.
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Lipid phosphatases SKIP and SHIP2 regulate fibronectin-dependent cell migration in glioblastoma.FEBS J. 2019 Mar;286(6):1120-1135. doi: 10.1111/febs.14769. Epub 2019 Feb 16.
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Reactive species balance via GTP cyclohydrolase I regulates glioblastoma growth and tumor initiating cell maintenance.Neuro Oncol. 2018 Jul 5;20(8):1055-1067. doi: 10.1093/neuonc/noy012.
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BMP9 counteracts the tumorigenic and pro-angiogenic potential of glioblastoma.Cell Death Differ. 2018 Nov;25(10):1808-1822. doi: 10.1038/s41418-018-0149-9. Epub 2018 Jul 5.
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Ex vivo-expanded highly purified natural killer cells in combination with temozolomide induce antitumor effects in human glioblastoma cells in vitro.PLoS One. 2019 Mar 6;14(3):e0212455. doi: 10.1371/journal.pone.0212455. eCollection 2019.
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Inhibition of GLO1 in Glioblastoma Multiforme Increases DNA-AGEs, Stimulates RAGE Expression, and Inhibits Brain Tumor Growth in Orthotopic Mouse Models.Int J Mol Sci. 2018 Jan 30;19(2):406. doi: 10.3390/ijms19020406.
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AMPA receptor antagonist perampanel affects glioblastoma cell growth and glutamate release in vitro.PLoS One. 2019 Feb 4;14(2):e0211644. doi: 10.1371/journal.pone.0211644. eCollection 2019.
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YAP and MRTF-A, transcriptional co-activators of RhoA-mediated gene expression, are critical for glioblastoma tumorigenicity.Oncogene. 2018 Oct;37(41):5492-5507. doi: 10.1038/s41388-018-0301-5. Epub 2018 Jun 11.
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Glioblastoma invasion and NMDA receptors: A novel prospect.Physiol Int. 2019 Sep 1;106(3):250-260. doi: 10.1556/2060.106.2019.22. Epub 2019 Sep 30.
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Identification of recurrent fusion genes across multiple cancer types.Sci Rep. 2019 Jan 31;9(1):1074. doi: 10.1038/s41598-019-38550-6.
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Metabotropic glutamate receptors as a new therapeutic target for malignant gliomas.Oncotarget. 2017 Mar 28;8(13):22279-22298. doi: 10.18632/oncotarget.15299.
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Identification of New Biomarkers Associated With IDH Mutation and Prognosis in Astrocytic Tumors Using NanoString nCounter Analysis System.Appl Immunohistochem Mol Morphol. 2018 Feb;26(2):101-107. doi: 10.1097/PAI.0000000000000396.
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Molecular mechanism of point mutation-induced Monopolar spindle 1 (Mps1/TTK) inhibitor resistance revealed by a comprehensive molecular modeling study.PeerJ. 2019 Jan 21;7:e6299. doi: 10.7717/peerj.6299. eCollection 2019.
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Phase I analysis of BCNU-impregnated biodegradable polymer wafers followed by systemic interferon alfa-2b in adults with recurrent glioblastoma multiforme.J Neurooncol. 2008 Dec;90(3):293-9. doi: 10.1007/s11060-008-9660-z. Epub 2008 Aug 5.
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STAT-1 expression is regulated by IGFBP-3 in malignant glioma cells and is a strong predictor of poor survival in patients with glioblastoma.J Neurosurg. 2014 Aug;121(2):374-83. doi: 10.3171/2014.4.JNS131198. Epub 2014 May 30.
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Analysis of the cancer genome atlas (TCGA) database identifies an inverse relationship between interleukin-13 receptor 1 and 2 gene expression and poor prognosis and drug resistance in subjects with glioblastoma multiforme.J Neurooncol. 2018 Feb;136(3):463-474. doi: 10.1007/s11060-017-2680-9. Epub 2017 Nov 22.
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Radiogenomics Profiling for Glioblastoma-related Immune Cells Reveals CD49d Expression Correlation with MRI parameters and Prognosis.Sci Rep. 2018 Oct 30;8(1):16022. doi: 10.1038/s41598-018-34242-9.
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CD103(+) Cell Growth Factor Flt3L Enhances the Efficacy of Immune Checkpoint Blockades in Murine Glioblastoma Model.Oncol Res. 2018 Mar 5;26(2):173-182. doi: 10.3727/096504017X14841698396865. Epub 2017 Jan 20.
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FAT1 modulates EMT and stemness genes expression in hypoxic glioblastoma.Int J Cancer. 2018 Feb 15;142(4):805-812. doi: 10.1002/ijc.31092. Epub 2017 Oct 17.
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Histone Acetyltransferase KAT6A Upregulates PI3K/AKT Signaling through TRIM24 Binding.Cancer Res. 2017 Nov 15;77(22):6190-6201. doi: 10.1158/0008-5472.CAN-17-1388. Epub 2017 Oct 11.
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Expression of voltage-gated potassium channels Kv1.3 and Kv1.5 in human gliomas.Neurosci Lett. 2003 Jul 31;346(1-2):33-6. doi: 10.1016/s0304-3940(03)00562-7.
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Overexpression of Large-Conductance Calcium-Activated Potassium Channels in Human Glioblastoma Stem-Like Cells and Their Role in Cell Migration.J Cell Physiol. 2017 Sep;232(9):2478-2488. doi: 10.1002/jcp.25592. Epub 2017 Apr 10.
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Lysine-Specific Demethylase 1 (LSD1/KDM1A) Is a Novel Target Gene of c-Myc.Biol Pharm Bull. 2019;42(3):481-488. doi: 10.1248/bpb.b18-00892.
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Phase II study of Dovitinib in recurrent glioblastoma.J Neurooncol. 2019 Sep;144(2):359-368. doi: 10.1007/s11060-019-03236-6. Epub 2019 Jul 11.
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LIM and SH3 protein 1 regulates cell growth and chemosensitivity of human glioblastoma via the PI3K/AKT pathway.BMC Cancer. 2018 Jul 6;18(1):722. doi: 10.1186/s12885-018-4649-2.
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LGR5 promotes tumorigenicity and invasion of glioblastoma stem-like cells and is a potential therapeutic target for a subset of glioblastoma patients.J Pathol. 2019 Feb;247(2):228-240. doi: 10.1002/path.5186. Epub 2019 Jan 10.
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Suppression of LIM Kinase 1 and LIM Kinase 2 Limits Glioblastoma Invasion.Cancer Res. 2020 Jan 1;80(1):69-78. doi: 10.1158/0008-5472.CAN-19-1237. Epub 2019 Oct 22.
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Inhibition of neurotensin receptor 1 induces intrinsic apoptosis via let-7a-3p/Bcl-w axis in glioblastoma.Br J Cancer. 2017 Jun 6;116(12):1572-1584. doi: 10.1038/bjc.2017.126. Epub 2017 May 11.
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Mutations in the mitotic check point gene, MAD1L1, in human cancers.Oncogene. 2001 May 31;20(25):3301-5. doi: 10.1038/sj.onc.1204421.
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Myristoylated alanine rich protein kinaseC substrate is a potential cancer prognostic factor that regulates cell migration and invasion in glioblastoma.Oncol Rep. 2019 Apr;41(4):2464-2470. doi: 10.3892/or.2019.7009. Epub 2019 Feb 13.
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Expression of the genes encoding myelin basic protein and proteolipid protein in human malignant gliomas.Clin Cancer Res. 1997 May;3(5):799-804.
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Delivery of siRNA in vitro and in vivo using PEI-capped porous silicon nanoparticles to silence MRP1 and inhibit proliferation in glioblastoma.J Nanobiotechnology. 2018 Apr 13;16(1):38. doi: 10.1186/s12951-018-0365-y.
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Arrestin-3 interaction with maternal embryonic leucine-zipper kinase.Cell Signal. 2019 Nov;63:109366. doi: 10.1016/j.cellsig.2019.109366. Epub 2019 Jul 25.
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Modulation of MKNK2 alternative splicing by splice-switching oligonucleotides as a novel approach for glioblastoma treatment.Nucleic Acids Res. 2018 Nov 30;46(21):11396-11404. doi: 10.1093/nar/gky921.
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Ultra-Mutation in IDH Wild-Type Glioblastomas of Patients Younger than 55 Years is Associated with Defective Mismatch Repair, Microsatellite Instability, and Giant Cell Enrichment.Cancers (Basel). 2019 Aug 30;11(9):1279. doi: 10.3390/cancers11091279.
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MSI2-TGF-/TGF- R1/SMAD3 positive feedback regulation in glioblastoma.Cancer Chemother Pharmacol. 2019 Aug;84(2):415-425. doi: 10.1007/s00280-019-03892-5. Epub 2019 Jun 27.
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Human cytomegalovirus ie2 affects the migration of glioblastoma by mediating the different splicing patterns of RON through hnRNP A2B1.Neuroreport. 2019 Aug 14;30(12):805-811. doi: 10.1097/WNR.0000000000001277.
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